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- W1994927488 abstract "Zinc is a metal known to be required for normal growth of both cells and organisms. When normal and SV40-transformed human tumor cells are plated and grown in medium containg zinc sulfate, a significant fraction of the transformed cells fail to grow at zinc concentrations which are relatively nontoxic to the normal fibroblasts. Although cultured cells respond to certain metallic ions by incresing their metallothionein content, no difference in the ability of normal and transformed cells to produce metallothionein in response to zinc exposure could be detected, thus ruling out this mechanism as a basic for the differing abilities of the cells to grwo in zinc in vitro. These results suggest that zinc may be capable of differntially regulating the growth of normal and SV40− transformed human fibroblasts." @default.
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- W1994927488 date "1982-01-01" @default.
- W1994927488 modified "2023-09-26" @default.
- W1994927488 title "SV40-transformed human cells fail to grow in zinc concentrations which permit normal human fibroblast proliferation" @default.
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- W1994927488 doi "https://doi.org/10.1002/jcp.1041100104" @default.
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