FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994928998> ?p ?o ?g. }

• W1994928998 endingPage "7551" @default.
• W1994928998 startingPage "7543" @default.
• W1994928998 abstract "Two series of new 6-alkoxy-4-substituted-aminoquinazolines (2–4f) and their bioisoteric quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors. The newly synthesized compounds were tested in vitro on human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. Most of the tested compounds exploited potent antitumor activity with IC50 values in the nanomolar range in particular compound 3b which displayed the highest activity among the tested compounds with IC50 equal to 0.13 nmol." @default.
• W1994928998 created "2016-06-24" @default.
• W1994928998 creator A5003776521 @default.
• W1994928998 creator A5061108079 @default.
• W1994928998 date "2008-08-01" @default.
• W1994928998 modified "2023-10-02" @default.
• W1994928998 title "Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase" @default.
• W1994928998 cites W1557061959 @default.
• W1994928998 cites W1629621594 @default.
• W1994928998 cites W1639582946 @default.
• W1994928998 cites W1964321121 @default.
• W1994928998 cites W1977161245 @default.
• W1994928998 cites W1984226397 @default.
• W1994928998 cites W1988345806 @default.
• W1994928998 cites W1996132368 @default.
• W1994928998 cites W1998281478 @default.
• W1994928998 cites W2009667440 @default.
• W1994928998 cites W2011924961 @default.
• W1994928998 cites W2023784605 @default.
• W1994928998 cites W2034919226 @default.
• W1994928998 cites W2043696829 @default.
• W1994928998 cites W2052664638 @default.
• W1994928998 cites W2065573847 @default.
• W1994928998 cites W2067013768 @default.
• W1994928998 cites W2074730236 @default.
• W1994928998 cites W2076184362 @default.
• W1994928998 cites W2084513035 @default.
• W1994928998 cites W2099895086 @default.
• W1994928998 cites W2109689528 @default.
• W1994928998 cites W2116931858 @default.
• W1994928998 cites W2128307445 @default.
• W1994928998 cites W2138778824 @default.
• W1994928998 cites W2139236349 @default.
• W1994928998 cites W2148346005 @default.
• W1994928998 cites W2161821474 @default.
• W1994928998 cites W2176558419 @default.
• W1994928998 cites W2178720405 @default.
• W1994928998 cites W2949357557 @default.
• W1994928998 cites W2949663766 @default.
• W1994928998 cites W4250453699 @default.
• W1994928998 doi "https://doi.org/10.1016/j.bmc.2008.07.038" @default.
• W1994928998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18678492" @default.
• W1994928998 hasPublicationYear "2008" @default.
• W1994928998 type Work @default.
• W1994928998 sameAs 1994928998 @default.
• W1994928998 citedByCount "88" @default.
• W1994928998 countsByYear W19949289982012 @default.
• W1994928998 countsByYear W19949289982013 @default.
• W1994928998 countsByYear W19949289982014 @default.
• W1994928998 countsByYear W19949289982015 @default.
• W1994928998 countsByYear W19949289982016 @default.
• W1994928998 countsByYear W19949289982017 @default.
• W1994928998 countsByYear W19949289982018 @default.
• W1994928998 countsByYear W19949289982019 @default.
• W1994928998 countsByYear W19949289982020 @default.
• W1994928998 countsByYear W19949289982021 @default.
• W1994928998 countsByYear W19949289982022 @default.
• W1994928998 countsByYear W19949289982023 @default.
• W1994928998 crossrefType "journal-article" @default.
• W1994928998 hasAuthorship W1994928998A5003776521 @default.
• W1994928998 hasAuthorship W1994928998A5061108079 @default.
• W1994928998 hasConcept C103697762 @default.
• W1994928998 hasConcept C114373084 @default.
• W1994928998 hasConcept C159110408 @default.
• W1994928998 hasConcept C170493617 @default.
• W1994928998 hasConcept C178790620 @default.
• W1994928998 hasConcept C185592680 @default.
• W1994928998 hasConcept C193042331 @default.
• W1994928998 hasConcept C202751555 @default.
• W1994928998 hasConcept C21951064 @default.
• W1994928998 hasConcept C2776309666 @default.
• W1994928998 hasConcept C2777506169 @default.
• W1994928998 hasConcept C2777752497 @default.
• W1994928998 hasConcept C2779438470 @default.
• W1994928998 hasConcept C41685203 @default.
• W1994928998 hasConcept C42362537 @default.
• W1994928998 hasConcept C54355233 @default.
• W1994928998 hasConcept C55493867 @default.
• W1994928998 hasConcept C56173144 @default.
• W1994928998 hasConcept C71240020 @default.
• W1994928998 hasConcept C71924100 @default.
• W1994928998 hasConcept C81885089 @default.
• W1994928998 hasConcept C86803240 @default.
• W1994928998 hasConcept C98274493 @default.
• W1994928998 hasConceptScore W1994928998C103697762 @default.
• W1994928998 hasConceptScore W1994928998C114373084 @default.
• W1994928998 hasConceptScore W1994928998C159110408 @default.
• W1994928998 hasConceptScore W1994928998C170493617 @default.
• W1994928998 hasConceptScore W1994928998C178790620 @default.
• W1994928998 hasConceptScore W1994928998C185592680 @default.
• W1994928998 hasConceptScore W1994928998C193042331 @default.
• W1994928998 hasConceptScore W1994928998C202751555 @default.
• W1994928998 hasConceptScore W1994928998C21951064 @default.
• W1994928998 hasConceptScore W1994928998C2776309666 @default.
• W1994928998 hasConceptScore W1994928998C2777506169 @default.
• W1994928998 hasConceptScore W1994928998C2777752497 @default.
• W1994928998 hasConceptScore W1994928998C2779438470 @default.
• W1994928998 hasConceptScore W1994928998C41685203 @default.

• next