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- W1994937897 abstract "This review focuses on wear debris-mediated osteolysis, a major factor compromising the long-term success of total joint arthroplasty. Studies on retrieved implants and animal models, as well as in vitro studies on particle bioreactivity, suggest that wear-mediated periprosthetic osteolysis is unlikely to be caused solely by 1 particular cell type or particulate species, but is rather the cumulative consequence of a number of biological reactions. Our recent findings suggest 3 novel mechanisms of particle bioreactivity that may contribute to osteolysis: 1) exacerbated inflammation caused by elevated reactive oxygen species production by activated macrophages and osteoclasts, (2) impaired periprosthetic bone formation secondary to disrupted osteogenesis, and (3) compromised bone regeneration resulting from increased cytotoxic response of mesenchymal osteoprogenitor cells. Understanding the pathogenesis of wear-mediated osteolysis is needed to improve orthopedic implant biocompatibility and wear reduction, and to develop effective pharmacotherapies." @default.
- W1994937897 created "2016-06-24" @default.
- W1994937897 creator A5010623364 @default.
- W1994937897 creator A5057499766 @default.
- W1994937897 creator A5080335637 @default.
- W1994937897 date "2004-12-01" @default.
- W1994937897 modified "2023-10-17" @default.
- W1994937897 title "Particle bioreactivity and wear-mediated osteolysis" @default.
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- W1994937897 doi "https://doi.org/10.1016/j.arth.2004.03.024" @default.
- W1994937897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15586339" @default.
- W1994937897 hasPublicationYear "2004" @default.
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