Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994943314> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W1994943314 abstract "Evolving young genomes of archaea, prokaryota and unicellular eukaryota were wide open for the acceptance of alien genomic sequences, which they often preserved and vertically transferred to their descendants throughout three billion years of evolution. Established complex large genomes, although seeded with ancestral retroelements, have come to regulate strictly their integrity. However, intruding retroelements, especially the descendents of Ty3/Gypsy, the chromoviruses, continue to find their ways into even the most established genomes. The simian and hominoid-Homo genomes preserved and accommodated a large number of endogenous retroviral genomic segments. These retroelements may mature into exogenous retroviruses, or into functional new genes. Phages and viruses have been instrumental in incorporating and transferring host cell genes. These events profoundly influenced and altered the course of evolution. Horizontal (lateral) gene transfers (HGT) overwhelmed the genomes of the ancient protocells and the evolving unicellular microorganisms, actually leading to their Cambrian explosion. While the rigidly organized genomes of multicellular organisms increasingly resist H/LGT, de-differentiated cells assuming the metabolism of their onto- or phylogenetic ancestors, open up widely to the practice of H/LGT by direct transfer, or to transfers mediated by viruses, or by cell fusions. This activity is intensified in malignantly transformed cells, thus rendering these subjects receptive to therapy with oncolytic viruses and with viral vectors of tumor-suppressive or immunogenic genetic materials. Naturally formed hybrids of dendritic and tumor cells are often tolerogenic, whereas laboratory products of these unisons may be immunogenic in the hosts of origin. As human breast cancer stem cells are induced by a treacherous class of CD8+ T cells to undergo epithelial to mesenchymal (ETM) transition and to yield to malignant transformation by the omnipresent proto-ocogenes (for example, the ras oncogenes), they become defenseless toward oncolytic viruses. Cell fusions and horizontal exchanges of genes are fundamental attributes and inherent characteristics of the living matter." @default.
- W1994943314 created "2016-06-24" @default.
- W1994943314 creator A5077880357 @default.
- W1994943314 date "2009-07-22" @default.
- W1994943314 modified "2023-10-01" @default.
- W1994943314 title "Horizontal gene transfers and cell fusions in microbiology, immunology and oncology (Review)" @default.
- W1994943314 doi "https://doi.org/10.3892/ijo_00000357" @default.
- W1994943314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19639166" @default.
- W1994943314 hasPublicationYear "2009" @default.
- W1994943314 type Work @default.
- W1994943314 sameAs 1994943314 @default.
- W1994943314 citedByCount "6" @default.
- W1994943314 countsByYear W19949433142013 @default.
- W1994943314 countsByYear W19949433142014 @default.
- W1994943314 countsByYear W19949433142015 @default.
- W1994943314 countsByYear W19949433142021 @default.
- W1994943314 crossrefType "journal-article" @default.
- W1994943314 hasAuthorship W1994943314A5077880357 @default.
- W1994943314 hasBestOaLocation W19949433141 @default.
- W1994943314 hasConcept C104317684 @default.
- W1994943314 hasConcept C141231307 @default.
- W1994943314 hasConcept C54355233 @default.
- W1994943314 hasConcept C74318829 @default.
- W1994943314 hasConcept C78458016 @default.
- W1994943314 hasConcept C86803240 @default.
- W1994943314 hasConcept C92938381 @default.
- W1994943314 hasConceptScore W1994943314C104317684 @default.
- W1994943314 hasConceptScore W1994943314C141231307 @default.
- W1994943314 hasConceptScore W1994943314C54355233 @default.
- W1994943314 hasConceptScore W1994943314C74318829 @default.
- W1994943314 hasConceptScore W1994943314C78458016 @default.
- W1994943314 hasConceptScore W1994943314C86803240 @default.
- W1994943314 hasConceptScore W1994943314C92938381 @default.
- W1994943314 hasIssue "5" @default.
- W1994943314 hasLocation W19949433141 @default.
- W1994943314 hasLocation W19949433142 @default.
- W1994943314 hasOpenAccess W1994943314 @default.
- W1994943314 hasPrimaryLocation W19949433141 @default.
- W1994943314 hasRelatedWork W2019988726 @default.
- W1994943314 hasRelatedWork W2128903938 @default.
- W1994943314 hasRelatedWork W2154486014 @default.
- W1994943314 hasRelatedWork W2166410860 @default.
- W1994943314 hasRelatedWork W2375007790 @default.
- W1994943314 hasRelatedWork W2499439908 @default.
- W1994943314 hasRelatedWork W2586888897 @default.
- W1994943314 hasRelatedWork W2793602347 @default.
- W1994943314 hasRelatedWork W3145445205 @default.
- W1994943314 hasRelatedWork W377826215 @default.
- W1994943314 hasVolume "35" @default.
- W1994943314 isParatext "false" @default.
- W1994943314 isRetracted "false" @default.
- W1994943314 magId "1994943314" @default.
- W1994943314 workType "article" @default.