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• W1994944745 startingPage "625" @default.
• W1994944745 abstract "Using heteroduplex molecules formed from a pair of plasmids, one of which contains a small deletion relative to the other, it is shown that bacterial topoisomerase I can relax a positively supercoiled DNA if a short single-stranded loop is placed in the DNA. This result supports the postulate that the specificity of bacterial DNA topoisomerase I for negatively supercoiled DNA in its relaxation reaction derives from the requirement of a short single-stranded DNA segment in the active enzyme-substrate complex. Nucleolytic and chemical probing of complexes between bacterial DNA topoisomerase I and heteroduplex DNA molecules containing single-stranded loops ranging from 13 to 27 nucleotides in length suggests that the enzyme binds specifically to the region containing a single-stranded loop; the site of DNA cleavage by the topoisomerase appears to lie within the single-stranded loop, with the enzyme interacting with nucleotides on both sides of the point of cleavage." @default.
• W1994944745 created "2016-06-24" @default.
• W1994944745 creator A5011866089 @default.
• W1994944745 creator A5073092630 @default.
• W1994944745 date "1985-10-01" @default.
• W1994944745 modified "2023-09-26" @default.
• W1994944745 title "Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop" @default.
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• W1994944745 doi "https://doi.org/10.1016/0022-2836(85)90075-0" @default.
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