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• W1994948000 abstract "Measurements of DNA conductivity, hybridization, and melting using electronic means can have wide applications in molecular electronics and biological sensors. We have fabricated nanogap break-junctions by electromigration through thin gold-on-titanium films. 18-mer thiolated ds-DNA molecules were covalently attached between the electrodes and dc electrical measurements were done. The conductance was measured through the molecule before and after a temperature ramp from 300 to 400 K. A dramatic decrease in conductance was observed, analogous to an electrical fuse, possibly attributed to complete or partial denaturing of the ds-DNA molecules bridging the nanogaps. We also show evidence that the dc resistance of dry DNA strands of the same length decreases with increasing guanine-cytosine content in the sequence with values ranging from 10 M Ω to 2 G Ω. These findings can have important consequences in DNA-based molecular electronics and direct label-free detection of DNA hybridization." @default.
• W1994948000 created "2016-06-24" @default.
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• W1994948000 date "2005-04-11" @default.
• W1994948000 modified "2023-09-26" @default.
• W1994948000 title "Direct current electrical characterization of ds-DNA in nanogap junctions" @default.
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• W1994948000 doi "https://doi.org/10.1063/1.1900315" @default.
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