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- W1994965483 abstract "Resveratrol and closely related stilbenoids belong to the most intensively studied biologically active compounds. This interest evoked several attempts to prepare such compounds in a convenient synthetic way. Our approach allowed obtaining largely methoxystilbenes, formed as E -isomers only (using Wittig–Horner synthesis as the key step), which were further demethylated by boron tribromide. The hydroxymethoxystilbenes (e.g. pterostilbene) were prepared using isopropyl protection, later selectively deprotected by boron trichloride. The method is suitable for preparing such compounds in a large amount. Effects of the obtained stilbene derivatives on immunobiological responses triggered by lipopolysacharide and interferon-γ were tested under in vitro conditions. Namely production of nitric oxide (NO) was investigated, and relation between the molecular structure and immunobiological activity was assessed." @default.
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- W1994965483 date "2010-01-01" @default.
- W1994965483 modified "2023-10-18" @default.
- W1994965483 title "Modified approach for preparing (E)-stilbenes related to resveratrol, and evaluation of their potential immunobiological effects" @default.
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- W1994965483 doi "https://doi.org/10.1135/cccc2009531" @default.
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