Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994966019> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1994966019 abstract "PURPOSE: To determine the functional effects of the resveratrol analog, pterostilbene (PTE), and its potential adjuvant role with cisplatin, in ovarian and uterine cancer cells. EXPERIMENTAL DESIGN: The human ovarian cancer cell lines (OVCAR8, SKOV3) and uterine cancer cell lines (HEC1A, ECC1) were obtained from ATCC, and grown according to standard protocols using recommended media. Standard proliferation (MTT) and migration assays were performed in routine fashion, with or without PTE +/- cisplatin treatment. For the in-vitro Cell Proliferation Assay, different concentrations of cisplatin (3 - 50 μM), pterostilbene (PTE) (30 - 500 μM), or both in combination were added for 72 hours. Cell migration was assayed using 24-mm diameter chambers with 8-μm pore filters, with or without treatment of PTE and cisplatin, and migrated cells were counted using Image-pro program. A synergistic analysis from the MTT assay results was calculated via the CompuSyn for Windows computer program based on the combination index (CI) theorem of Chou-Talalay, to determine the presence of synergy between cisplatin and PTE. RESULTS: PTE reduces proliferation in OVCAR8, SKOV3, HEC1A, and ECC1 cells, and its anti-proliferative effect approaches that of cisplatin. Addition of PTE to cisplatin potentiates the anti-proliferative effects of cisplatin in HEC1A, ECC1, SKOV3, and OVCAR8 cells. The combined effect of PTE and cisplatin is synergistic in OVCAR8 cells based on synergy calculations (CI CONCLUSIONS: Pterostilbene, a resveratrol analog with improved bioavailability, reduces proliferation and migration in ovarian and uterine cancer cells, and potentiates the anti-proliferative and anti-migratory effects of cisplatin, thus presenting as an attractive non-toxic alternative for potential adjuvant chemotherapy in ovarian and uterine cancer. Citation Format: Gina Lowe, Wei Wen, Cai Roberts, James Finlay, Carlotta Glackin, Ernest Han, Thanh H. Dellinger. Role of pterostilbene on proliferation, invasion, and migration in ovarian and uterine cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3215. doi:10.1158/1538-7445.AM2014-3215" @default.
- W1994966019 created "2016-06-24" @default.
- W1994966019 creator A5013792176 @default.
- W1994966019 creator A5015621604 @default.
- W1994966019 creator A5034012906 @default.
- W1994966019 creator A5047237088 @default.
- W1994966019 creator A5057464314 @default.
- W1994966019 creator A5064008571 @default.
- W1994966019 creator A5072955109 @default.
- W1994966019 date "2014-09-30" @default.
- W1994966019 modified "2023-09-25" @default.
- W1994966019 title "Abstract 3215: Role of pterostilbene on proliferation, invasion, and migration in ovarian and uterine cancer cells" @default.
- W1994966019 doi "https://doi.org/10.1158/1538-7445.am2014-3215" @default.
- W1994966019 hasPublicationYear "2014" @default.
- W1994966019 type Work @default.
- W1994966019 sameAs 1994966019 @default.
- W1994966019 citedByCount "0" @default.
- W1994966019 crossrefType "proceedings-article" @default.
- W1994966019 hasAuthorship W1994966019A5013792176 @default.
- W1994966019 hasAuthorship W1994966019A5015621604 @default.
- W1994966019 hasAuthorship W1994966019A5034012906 @default.
- W1994966019 hasAuthorship W1994966019A5047237088 @default.
- W1994966019 hasAuthorship W1994966019A5057464314 @default.
- W1994966019 hasAuthorship W1994966019A5064008571 @default.
- W1994966019 hasAuthorship W1994966019A5072955109 @default.
- W1994966019 hasConcept C121608353 @default.
- W1994966019 hasConcept C126322002 @default.
- W1994966019 hasConcept C185592680 @default.
- W1994966019 hasConcept C2776694085 @default.
- W1994966019 hasConcept C2776816829 @default.
- W1994966019 hasConcept C2778239845 @default.
- W1994966019 hasConcept C2778515176 @default.
- W1994966019 hasConcept C2780427987 @default.
- W1994966019 hasConcept C2780783641 @default.
- W1994966019 hasConcept C2781196776 @default.
- W1994966019 hasConcept C502942594 @default.
- W1994966019 hasConcept C55493867 @default.
- W1994966019 hasConcept C62112901 @default.
- W1994966019 hasConcept C71924100 @default.
- W1994966019 hasConcept C96232424 @default.
- W1994966019 hasConcept C98274493 @default.
- W1994966019 hasConceptScore W1994966019C121608353 @default.
- W1994966019 hasConceptScore W1994966019C126322002 @default.
- W1994966019 hasConceptScore W1994966019C185592680 @default.
- W1994966019 hasConceptScore W1994966019C2776694085 @default.
- W1994966019 hasConceptScore W1994966019C2776816829 @default.
- W1994966019 hasConceptScore W1994966019C2778239845 @default.
- W1994966019 hasConceptScore W1994966019C2778515176 @default.
- W1994966019 hasConceptScore W1994966019C2780427987 @default.
- W1994966019 hasConceptScore W1994966019C2780783641 @default.
- W1994966019 hasConceptScore W1994966019C2781196776 @default.
- W1994966019 hasConceptScore W1994966019C502942594 @default.
- W1994966019 hasConceptScore W1994966019C55493867 @default.
- W1994966019 hasConceptScore W1994966019C62112901 @default.
- W1994966019 hasConceptScore W1994966019C71924100 @default.
- W1994966019 hasConceptScore W1994966019C96232424 @default.
- W1994966019 hasConceptScore W1994966019C98274493 @default.
- W1994966019 hasLocation W19949660191 @default.
- W1994966019 hasOpenAccess W1994966019 @default.
- W1994966019 hasPrimaryLocation W19949660191 @default.
- W1994966019 hasRelatedWork W1979209078 @default.
- W1994966019 hasRelatedWork W1994504180 @default.
- W1994966019 hasRelatedWork W2074786285 @default.
- W1994966019 hasRelatedWork W2078389281 @default.
- W1994966019 hasRelatedWork W2081010396 @default.
- W1994966019 hasRelatedWork W2350495671 @default.
- W1994966019 hasRelatedWork W2355422040 @default.
- W1994966019 hasRelatedWork W2361659734 @default.
- W1994966019 hasRelatedWork W2370496740 @default.
- W1994966019 hasRelatedWork W2380730576 @default.
- W1994966019 hasRelatedWork W2383346452 @default.
- W1994966019 hasRelatedWork W2522879835 @default.
- W1994966019 hasRelatedWork W2901642092 @default.
- W1994966019 hasRelatedWork W2984763078 @default.
- W1994966019 hasRelatedWork W2990454547 @default.
- W1994966019 hasRelatedWork W3007626256 @default.
- W1994966019 hasRelatedWork W3037949712 @default.
- W1994966019 hasRelatedWork W3047574877 @default.
- W1994966019 hasRelatedWork W3132536287 @default.
- W1994966019 hasRelatedWork W3171262102 @default.
- W1994966019 isParatext "false" @default.
- W1994966019 isRetracted "false" @default.
- W1994966019 magId "1994966019" @default.
- W1994966019 workType "article" @default.