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- W1994967294 endingPage "178" @default.
- W1994967294 startingPage "169" @default.
- W1994967294 abstract "Studies with the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson’s disease have shown the ability of 17β-estradiol to protect the nigrostriatal dopaminergic system. This paper reviews the signaling pathways mediating the neuroprotective effect of 17β-estradiol against MPTP-induced toxicity. The mechanisms of 17β-estradiol action implicate activation of signaling pathways such as the phosphatidylinositol-3 kinase/Akt and the mitogen-activated protein kinase pathways. 17β-estradiol signaling is complex and integrates multiple interactions with signaling molecules that act to potentiate a protective effect. 17β-estradiol signaling is mediated via estrogen receptors, including GPER1, but others receptors, such as the IGF-1 receptor, are implicated in the neuroprotective effect. Glial and neuronal crosstalk is a critical factor in the maintenance of dopamine neuronal survival and in the neuroprotective action of 17β-estradiol. Compounds that stimulate GPER1 such as selective estrogen receptor modulators and phytoestrogens show neuroprotective activity and are alternatives to 17β-estradiol." @default.
- W1994967294 created "2016-06-24" @default.
- W1994967294 creator A5029887779 @default.
- W1994967294 creator A5080421244 @default.
- W1994967294 creator A5044103729 @default.
- W1994967294 date "2012-04-01" @default.
- W1994967294 modified "2023-09-26" @default.
- W1994967294 title "Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson’s disease" @default.
- W1994967294 cites W1509103176 @default.
- W1994967294 cites W1529774113 @default.
- W1994967294 cites W1532405140 @default.
- W1994967294 cites W1550159293 @default.
- W1994967294 cites W1551831696 @default.
- W1994967294 cites W175348630 @default.
- W1994967294 cites W1809411463 @default.
- W1994967294 cites W1838634581 @default.
- W1994967294 cites W1899159574 @default.
- W1994967294 cites W1965366482 @default.
- W1994967294 cites W1968126004 @default.
- W1994967294 cites W1968507832 @default.
- W1994967294 cites W1968998907 @default.
- W1994967294 cites W1969715795 @default.
- W1994967294 cites W1969800514 @default.
- W1994967294 cites W1974994389 @default.
- W1994967294 cites W1974997673 @default.
- W1994967294 cites W1975112659 @default.
- W1994967294 cites W1975205756 @default.
- W1994967294 cites W1975774284 @default.
- W1994967294 cites W1975941800 @default.
- W1994967294 cites W1978025210 @default.
- W1994967294 cites W1981467972 @default.
- W1994967294 cites W1984479644 @default.
- W1994967294 cites W1985323921 @default.
- W1994967294 cites W1987811547 @default.
- W1994967294 cites W1989573061 @default.
- W1994967294 cites W1989771766 @default.
- W1994967294 cites W1990000696 @default.
- W1994967294 cites W1991966343 @default.
- W1994967294 cites W1994526084 @default.
- W1994967294 cites W1995923209 @default.
- W1994967294 cites W1996316175 @default.
- W1994967294 cites W1998136871 @default.
- W1994967294 cites W1998396025 @default.
- W1994967294 cites W1999649731 @default.
- W1994967294 cites W2002190647 @default.
- W1994967294 cites W2002845655 @default.
- W1994967294 cites W2002867773 @default.
- W1994967294 cites W2003074165 @default.
- W1994967294 cites W2003241128 @default.
- W1994967294 cites W2004065307 @default.
- W1994967294 cites W2005547107 @default.
- W1994967294 cites W2005907346 @default.
- W1994967294 cites W2008820856 @default.
- W1994967294 cites W2014754503 @default.
- W1994967294 cites W2015307784 @default.
- W1994967294 cites W2015555425 @default.
- W1994967294 cites W2016213053 @default.
- W1994967294 cites W2017814736 @default.
- W1994967294 cites W2018651845 @default.
- W1994967294 cites W2019333118 @default.
- W1994967294 cites W2023404393 @default.
- W1994967294 cites W2023961220 @default.
- W1994967294 cites W2024089136 @default.
- W1994967294 cites W2024344832 @default.
- W1994967294 cites W2025595769 @default.
- W1994967294 cites W2026463041 @default.
- W1994967294 cites W2027548273 @default.
- W1994967294 cites W2029777052 @default.
- W1994967294 cites W2033616185 @default.
- W1994967294 cites W2033711513 @default.
- W1994967294 cites W2035685439 @default.
- W1994967294 cites W2038224182 @default.
- W1994967294 cites W2039194156 @default.
- W1994967294 cites W2041619394 @default.
- W1994967294 cites W2045616163 @default.
- W1994967294 cites W2047677635 @default.
- W1994967294 cites W2049559677 @default.
- W1994967294 cites W2051120662 @default.
- W1994967294 cites W2052004566 @default.
- W1994967294 cites W2052595266 @default.
- W1994967294 cites W2053036896 @default.
- W1994967294 cites W2055739274 @default.
- W1994967294 cites W2058252177 @default.
- W1994967294 cites W2058594344 @default.
- W1994967294 cites W2061028746 @default.
- W1994967294 cites W2065275335 @default.
- W1994967294 cites W2066546360 @default.
- W1994967294 cites W2068120156 @default.
- W1994967294 cites W2069491947 @default.
- W1994967294 cites W2070293233 @default.
- W1994967294 cites W2072595147 @default.
- W1994967294 cites W2072735944 @default.
- W1994967294 cites W2073576669 @default.
- W1994967294 cites W2073672013 @default.
- W1994967294 cites W2075443461 @default.
- W1994967294 cites W2076485183 @default.
- W1994967294 cites W2078577857 @default.
- W1994967294 cites W2080033986 @default.