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- W1994975810 abstract "Lipopolysaccharides (LPS) isolated from oral strains of Veillonella, Fusobacterium and Bacteroides stimulated the release of 45Ca from prelabeled fetal rat bones in culture. There was a typical dose-response relationship berween the quantities of released 45Ca and LPS used for stimulation. Bacteroides-LPS proved to be the less active inducer of 45Ca release. LPS had no stimulating effect on the release of 45Ca from devitalized bone. The stimulated 45Ca release was paralleled by an increase in the culture midium of hydroxyproline and lactate. This, together with the findings of numerous osteoclasts in stained hisological specimens of the experimental bones, indicates that LPS stimulated the osteoclasts to bone resoption. Heparin, which did not directly induce 45Ca release, potentiated the bone resorption stimulating capability of LPS. The lipid A and the polysaccharide portion of Fusobacterium LPS also stimulated bone resorption and, remarkably, the polysaccharide portion showed the greatest activity. This may explain the mode of action of LPS lacking a typical lipid A. It is suggested that stimulation of osteoclasts by LPS may result from activation of complement by lipid A or its polysaccharide portion." @default.
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- W1994975810 date "2007-10-01" @default.
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- W1994975810 title "Bone resorption stimulated by lipopolysaccharides from Bacteroides, Fusobacterium and Veillonella, and by the lipid A and the polysaccharide part of Fusobacterium lipopolyccharide" @default.
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- W1994975810 doi "https://doi.org/10.1111/j.1600-0722.1980.tb01264.x" @default.
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