FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994977897> ?p ?o ?g. }

• W1994977897 endingPage "376" @default.
• W1994977897 startingPage "370" @default.
• W1994977897 abstract "The isolation to purity of a rat liver mitochondrial thioredoxin reductase is reported. The mitochondrial enzyme shows a chromatographic behavior different from that of the cytosolic enzyme. The purified enzyme, after sodium dodecylsulfate-polyacrylamide gel electrophoresis, yields a single band with a molecular weight of approximately 54 kDa. The apparent Km for E. coli thioredoxin is about 13 microM, while the apparent Km for 5,5'-dithiobis (2-nitrobenzoic acid) is 530 microM, values comparable to those reported for the cytosolic enzyme. Mitochondrial thioredoxin reductase, in addition to its natural substrate thioredoxin, is also able to reduce chemically unrelated compounds such as 5,5 '-dithiobis (2-nitrobenzoic acid), selenite, and alloxan; the enzyme is inhibited by classical inhibitors of the cytosolic enzyme such as 1-chloro-2,4-dinitrobenzene and 13-cis-retinoic acid. A strong inhibitory action is also elicited by Mn2+ and Zn2+ ions. Thiol status appears critically involved in the control of membrane permeability and, therefore, a thiol/disulfide transition involving reduced pyridine nucleotides, matrix soluble thiols, and inner membrane thiols appears to play a fundamental role. The potential role of thioredoxin/thioredoxin reductase system in the control and redox regulation of the mitochondrial membrane permeability, is discussed." @default.
• W1994977897 created "2016-06-24" @default.
• W1994977897 creator A5003801118 @default.
• W1994977897 creator A5046780479 @default.
• W1994977897 creator A5049824727 @default.
• W1994977897 creator A5057969082 @default.
• W1994977897 creator A5061806514 @default.
• W1994977897 date "1998-01-01" @default.
• W1994977897 modified "2023-10-01" @default.
• W1994977897 title "Purification of Mitochondrial Thioredoxin Reductase and Its Involvement in the Redox Regulation of Membrane Permeability" @default.
• W1994977897 cites W119802141 @default.
• W1994977897 cites W1487157100 @default.
• W1994977897 cites W150246076 @default.
• W1994977897 cites W1506043065 @default.
• W1994977897 cites W1513390880 @default.
• W1994977897 cites W1550007121 @default.
• W1994977897 cites W1555938743 @default.
• W1994977897 cites W1598280952 @default.
• W1994977897 cites W1775749144 @default.
• W1994977897 cites W1930274950 @default.
• W1994977897 cites W1976240560 @default.
• W1994977897 cites W1987338970 @default.
• W1994977897 cites W1992533564 @default.
• W1994977897 cites W2008757391 @default.
• W1994977897 cites W2015761737 @default.
• W1994977897 cites W2019851957 @default.
• W1994977897 cites W2027874650 @default.
• W1994977897 cites W2034260628 @default.
• W1994977897 cites W2036599441 @default.
• W1994977897 cites W2039759271 @default.
• W1994977897 cites W2048971811 @default.
• W1994977897 cites W2050425916 @default.
• W1994977897 cites W2063385957 @default.
• W1994977897 cites W2074513437 @default.
• W1994977897 cites W2076762664 @default.
• W1994977897 cites W2087596337 @default.
• W1994977897 cites W2100837269 @default.
• W1994977897 cites W2197332903 @default.
• W1994977897 cites W2238161028 @default.
• W1994977897 cites W4247896860 @default.
• W1994977897 doi "https://doi.org/10.1016/s0891-5849(97)00216-5" @default.
• W1994977897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9433913" @default.
• W1994977897 hasPublicationYear "1998" @default.
• W1994977897 type Work @default.
• W1994977897 sameAs 1994977897 @default.
• W1994977897 citedByCount "128" @default.
• W1994977897 countsByYear W19949778972012 @default.
• W1994977897 countsByYear W19949778972013 @default.
• W1994977897 countsByYear W19949778972014 @default.
• W1994977897 countsByYear W19949778972015 @default.
• W1994977897 countsByYear W19949778972016 @default.
• W1994977897 countsByYear W19949778972017 @default.
• W1994977897 countsByYear W19949778972018 @default.
• W1994977897 countsByYear W19949778972019 @default.
• W1994977897 countsByYear W19949778972020 @default.
• W1994977897 countsByYear W19949778972021 @default.
• W1994977897 countsByYear W19949778972023 @default.
• W1994977897 crossrefType "journal-article" @default.
• W1994977897 hasAuthorship W1994977897A5003801118 @default.
• W1994977897 hasAuthorship W1994977897A5046780479 @default.
• W1994977897 hasAuthorship W1994977897A5049824727 @default.
• W1994977897 hasAuthorship W1994977897A5057969082 @default.
• W1994977897 hasAuthorship W1994977897A5061806514 @default.
• W1994977897 hasConcept C134651460 @default.
• W1994977897 hasConcept C181199279 @default.
• W1994977897 hasConcept C185592680 @default.
• W1994977897 hasConcept C2777737464 @default.
• W1994977897 hasConcept C2781324293 @default.
• W1994977897 hasConcept C28859421 @default.
• W1994977897 hasConcept C3623737 @default.
• W1994977897 hasConcept C55493867 @default.
• W1994977897 hasConcept C75385678 @default.
• W1994977897 hasConcept C98539663 @default.
• W1994977897 hasConceptScore W1994977897C134651460 @default.
• W1994977897 hasConceptScore W1994977897C181199279 @default.
• W1994977897 hasConceptScore W1994977897C185592680 @default.
• W1994977897 hasConceptScore W1994977897C2777737464 @default.
• W1994977897 hasConceptScore W1994977897C2781324293 @default.
• W1994977897 hasConceptScore W1994977897C28859421 @default.
• W1994977897 hasConceptScore W1994977897C3623737 @default.
• W1994977897 hasConceptScore W1994977897C55493867 @default.
• W1994977897 hasConceptScore W1994977897C75385678 @default.
• W1994977897 hasConceptScore W1994977897C98539663 @default.
• W1994977897 hasIssue "2" @default.
• W1994977897 hasLocation W19949778971 @default.
• W1994977897 hasLocation W19949778972 @default.
• W1994977897 hasOpenAccess W1994977897 @default.
• W1994977897 hasPrimaryLocation W19949778971 @default.
• W1994977897 hasRelatedWork W1591929009 @default.
• W1994977897 hasRelatedWork W1668614192 @default.
• W1994977897 hasRelatedWork W2007608783 @default.
• W1994977897 hasRelatedWork W2017627654 @default.
• W1994977897 hasRelatedWork W2037840011 @default.
• W1994977897 hasRelatedWork W2084004698 @default.
• W1994977897 hasRelatedWork W2090244729 @default.
• W1994977897 hasRelatedWork W2588591921 @default.
• W1994977897 hasRelatedWork W3180340671 @default.
• W1994977897 hasRelatedWork W4248449930 @default.

• next