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• W1994978035 startingPage "e108010" @default.
• W1994978035 abstract "Long noncoding RNAs (lncRNAs) are noncoding transcripts longer than 200 nucleotides, which show evidence of pervasive transcription and participate in a plethora of cellular regulatory processes. Although several noncoding transcripts have been functionally annotated as lncRNAs within the genome, not all have been proven to fulfill the criteria for a functional regulator and further analyses have to be done in order to include them in a functional cohort. LncRNAs are being classified and reclassified in an ongoing annotation process, and the challenge is fraught with ambiguity, as newer evidences of their biogenesis and functional implication come into light. In our effort to understand the complexity of this still enigmatic biomolecule, we have developed a new database entitled LncRBase where we have classified and characterized lncRNAs in human and mouse. It is an extensive resource of human and mouse lncRNA transcripts belonging to fourteen distinct subtypes, with a total of 83,201 entries for mouse and 133,361 entries for human: among these, we have newly annotated 8,507 mouse and 14,813 human non coding RNA transcripts (from UCSC and H-InvDB 8.0) as lncRNAs. We have especially considered protein coding gene loci which act as hosts for non coding transcripts. LncRBase includes different lncRNA transcript variants of protein coding genes within LncRBase. LncRBase provides information about the genomic context of different lncRNA subtypes, their interaction with small non coding RNAs (ncRNAs) viz. piwi interacting RNAs (piRNAs) and microRNAs (miRNAs) and their mode of regulation, via association with diverse other genomic elements. Adequate knowledge about genomic origin and molecular features of lncRNAs is essential to understand their functional and behavioral complexities. Overall, LncRBase provides a thorough study on various aspects of lncRNA origin and function and a user-friendly interface to search for lncRNA information. LncRBase is available at http://bicresources.jcbose.ac.in/zhumur/lncrbase." @default.
• W1994978035 created "2016-06-24" @default.
• W1994978035 creator A5001591003 @default.
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• W1994978035 date "2014-09-18" @default.
• W1994978035 modified "2023-09-30" @default.
• W1994978035 title "LncRBase: An Enriched Resource for lncRNA Information" @default.
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• W1994978035 doi "https://doi.org/10.1371/journal.pone.0108010" @default.
• W1994978035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4169474" @default.
• W1994978035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25233092" @default.
• W1994978035 hasPublicationYear "2014" @default.
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