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- W1994987382 abstract "Oligonucleotide derivatives capable of binding to specific nucleic acids are considered as potential therapeutic agents, exerting their action at the level of genome functioning (Hélène, 1991; Knorre et al., 1993). A straightforward approach to targeting DNA is based on using oligonucleotides capable of binding to oligopurine-oligopyrimidine sequences by formation of triple-strand structures. We report results of experiments on sequence-specific chemical modification of a 490-bp fragment of pfosCAT plasmid, containing the promoter segment of the c-fos gene using 4-(N-2-chloroethyl-N-methylamino)-benzylphosphamide derivatives of a homopyrimidine 14-mer oligonucleotide. It was shown that in both the free DNA and the DNA involved in nucleosome structure, reaction occurred with similar efficiency at the target guanosine residue G404." @default.
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- W1994987382 date "1999-12-01" @default.
- W1994987382 modified "2023-09-25" @default.
- W1994987382 title "Formation of Nucleosomes Does Not Suppress Interaction of a DNA Fragment with an Alkylating Derivative of a Pyrimidine Oligonucleotide" @default.
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- W1994987382 doi "https://doi.org/10.1089/oli.1.1999.9.533" @default.
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