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• W1994999743 abstract "El sistema renina-angiotensina-aldosterona (SRAA) es un importante regulador de la función cardiovascular y renal. Su bloqueo mediante los inhibidores de la enzima conversiva de la angiotensina (ECA) y/o los antagonistas del receptor de la angiotensina II se acompaña de una reducción de los valores de presión arterial, reducción del riesgo cardiovascular y enlentecimiento de la progresión de la insuficiencia renal. El descubrimiento de la ECA2, una enzima homóloga de la ECA encargada de la degradación de la angiotensina II a angiotensina 1-7, ofrece una nueva línea de estudio en el SRAA. La presente revision expone la importancia de la ECA2 en diferentes órganos: el corazón, el pulmón y el riñón. A su vez, se detalla la importancia de dicha enzima mediante los diversos estudios realizados en modelos genéticamente manipulados con deleción del gen de la ECA2 y mediante la administración de un inhibidor de la ECA2. Los resultados de dichos estudios apuntan a un papel emergente de la ECA2 como una nueva diana terapéutica del SRAA. The renin-angiotensin system (RAS) plays a key role in the regulation of cardiovascular and renal function. Thus, RAS blockade with an angiotensin- converting enzyme (ACE) and/or angiotensin receptor blocker decreases blood pressure, cardiovascular events, and delays the progression of kidney disease. The discovery of ACE2, a homologue of ACE, capable of degrading angiotensin II to angiotensin 1-7, may offer new insights into the RAS. In this review we discuss the possible protective role of ACE2 in different organs, namely heart, lungs and kidneys. The role of this enzyme is inferred from recent studies performed using genetically manipulated mice that lack the ACE2 gene and also mice treated with pharmacological ACE2 inhibitors. These results suggest that ACE2 might be a new therapeutic target within the RAS." @default.
• W1994999743 created "2016-06-24" @default.
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• W1994999743 date "2008-07-01" @default.
• W1994999743 modified "2023-10-01" @default.
• W1994999743 title "Enzima conversiva de la angiotensina 2 y su papel emergente en la regulación del sistema renina-angiotensina" @default.
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• W1994999743 doi "https://doi.org/10.1157/13124619" @default.
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