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• W1995003441 abstract "<i>Background:</i> In any context of iron supplementation in the prenatal prophylaxis or therapeutic dosage range, a large amount will remain unabsorbed and pass through the intestinal tract into the colonic digesta possibly causing increased oxidation. <i>Aim:</i> To compare the generation of fecal reactive oxygen species (ROS) in situ after daily consumption of 100 mg of elemental iron in three frequently used forms of iron supplements. <i>Methods:</i> Ten healthy, iron-repleted adult males were investigated before and during supplementation with three oral iron compounds: 100 mg of oral iron were given as ferrous sulfate, Na Fe-EDTA and iron polymaltose for 6 days to each subject in an individually stratified sequence. Stool samples were collected and analyzed for iron content and the in situ generation of fecal ROS. <i>Results:</i> Significant increases in fecal ROS generation were observed during oral iron supplementation. No statistical differences were seen in either residual concentrations of non-heme iron in stool or the level of fecal ROS generation between the three Fe compounds. There was, however, a significant association between the iron concentration in the stool and ROS generation. <i>Conclusion:</i> In spite of the differences in their chemical characteristics, none of the three distinct iron complexes reduced oxidative stress in the intestinal lumen." @default.
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• W1995003441 date "2012-01-01" @default.
• W1995003441 modified "2023-10-14" @default.
• W1995003441 title "Equivalent Effects on Fecal Reactive Oxygen Species Generation with Oral Supplementation of Three Iron Compounds: Ferrous Sulfate, Sodium Iron EDTA and Iron Polymaltose" @default.
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• W1995003441 doi "https://doi.org/10.1159/000336181" @default.
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