Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995005384> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1995005384 endingPage "187" @default.
- W1995005384 startingPage "187" @default.
- W1995005384 abstract "433 Administration of donor splenocytes or bone marrow enhances the salutary effect of B7-CD28 costimulation blockade on allograft survival in rodents. Because IFNγ has important immunoregulatory functions, we addressed whether this cytokine plays a role in DSST+CTLA4Ig-mediated immunosuppression by comparing the survival of fully allogeneic cardiac or skin grafts in wildtype (IFNγ+/+) recipients to that in IFNγ gene-knockout(IFNγ-/-) mice. DSST (1 × 107 donor splenocytes) was administered i.v. at the time of transplantation. CTLA4Ig (200μg) was administered i.p. in a single dose two days after transplantation. Cardiac rejection was defined as cessation of palpable heart beat and was confirmed histologically. Skin rejection was defined as >90% necrosis of the graft(trunk skin). Results: DSST+CTLA4Ig-mediated prolongation of cardiac allograft survival (C3H/He → BALB/c) was significantly greater in IFNγ+/+ than IFNγ-/- recipients:TableThese data are consistent with our previous findings that endogenous IFNγ facilitates induction of longterm cardiac allograft survival in mice treated with CTLA4Ig alone. Similarly, DSST+CTLA4Ig-mediated prolongation of skin allograft survival(BALB/c → C57BL/6), although modest, was significantly greater in IFNγ+/+ than IFNγ-/- recipients:TableConclusions: (1) Endogenous IFNγ does not hinder but rather facilitates induction of longterm allograft survival in mice treated with donor-specific splenocyte transfusion and CTLA4Ig. (2) These preliminary data suggest that IFNγ plays an essential regulatory role in alloimmunity. Because cyclosporine inhibits IFNγ production, cyclosporine could abrogate the potential clinical utility of donor blood, bone marrow, or splenocyte administration to recipients of solid organ allografts." @default.
- W1995005384 created "2016-06-24" @default.
- W1995005384 creator A5012114424 @default.
- W1995005384 creator A5022352244 @default.
- W1995005384 creator A5057604042 @default.
- W1995005384 creator A5065576722 @default.
- W1995005384 creator A5073466889 @default.
- W1995005384 date "1998-05-01" @default.
- W1995005384 modified "2023-09-27" @default.
- W1995005384 title "INTERFERON-GAMMA (IFNγ) IS REQUIRED FOR LONGTERM ALLOGRAFT SURVIVAL INDUCED BY COMBINED ADMINISTRATION OF DONOR-SPECIFIC SPLENOCYTE TRANSFUSION(DSST) AND CTLA4Ig." @default.
- W1995005384 doi "https://doi.org/10.1097/00007890-199805131-00431" @default.
- W1995005384 hasPublicationYear "1998" @default.
- W1995005384 type Work @default.
- W1995005384 sameAs 1995005384 @default.
- W1995005384 citedByCount "0" @default.
- W1995005384 crossrefType "journal-article" @default.
- W1995005384 hasAuthorship W1995005384A5012114424 @default.
- W1995005384 hasAuthorship W1995005384A5022352244 @default.
- W1995005384 hasAuthorship W1995005384A5057604042 @default.
- W1995005384 hasAuthorship W1995005384A5065576722 @default.
- W1995005384 hasAuthorship W1995005384A5073466889 @default.
- W1995005384 hasBestOaLocation W19950053841 @default.
- W1995005384 hasConcept C126322002 @default.
- W1995005384 hasConcept C189976730 @default.
- W1995005384 hasConcept C203014093 @default.
- W1995005384 hasConcept C2778690821 @default.
- W1995005384 hasConcept C2780252810 @default.
- W1995005384 hasConcept C2780841837 @default.
- W1995005384 hasConcept C2780931953 @default.
- W1995005384 hasConcept C2911091166 @default.
- W1995005384 hasConcept C71924100 @default.
- W1995005384 hasConcept C98274493 @default.
- W1995005384 hasConceptScore W1995005384C126322002 @default.
- W1995005384 hasConceptScore W1995005384C189976730 @default.
- W1995005384 hasConceptScore W1995005384C203014093 @default.
- W1995005384 hasConceptScore W1995005384C2778690821 @default.
- W1995005384 hasConceptScore W1995005384C2780252810 @default.
- W1995005384 hasConceptScore W1995005384C2780841837 @default.
- W1995005384 hasConceptScore W1995005384C2780931953 @default.
- W1995005384 hasConceptScore W1995005384C2911091166 @default.
- W1995005384 hasConceptScore W1995005384C71924100 @default.
- W1995005384 hasConceptScore W1995005384C98274493 @default.
- W1995005384 hasIssue "Supplement" @default.
- W1995005384 hasLocation W19950053841 @default.
- W1995005384 hasLocation W19950053842 @default.
- W1995005384 hasOpenAccess W1995005384 @default.
- W1995005384 hasPrimaryLocation W19950053841 @default.
- W1995005384 hasRelatedWork W1985144436 @default.
- W1995005384 hasRelatedWork W2002710000 @default.
- W1995005384 hasRelatedWork W2034796349 @default.
- W1995005384 hasRelatedWork W2110761918 @default.
- W1995005384 hasRelatedWork W2136175148 @default.
- W1995005384 hasRelatedWork W2139012968 @default.
- W1995005384 hasRelatedWork W2271232808 @default.
- W1995005384 hasRelatedWork W2576837937 @default.
- W1995005384 hasRelatedWork W2924378690 @default.
- W1995005384 hasRelatedWork W632228299 @default.
- W1995005384 hasVolume "65" @default.
- W1995005384 isParatext "false" @default.
- W1995005384 isRetracted "false" @default.
- W1995005384 magId "1995005384" @default.
- W1995005384 workType "article" @default.