FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995011648> ?p ?o ?g. }

• W1995011648 endingPage "1464" @default.
• W1995011648 startingPage "1451" @default.
• W1995011648 abstract "Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. We report the synthesis and the pharmacological evaluation of a new class of human carbonic anhydrase (hCA) inhibitors, 4-(5-aryl-2-hydroxymethyl-pyrazol-1-yl)-benzenesulfonamides. A molecular modeling study was conducted in order to simulate the binding mode of this new family of enzyme inhibitors within the active site of hCA IX. Pharmacological studies revealed high hCA IX inhibitory potency in the parameters nanomolar range. This study showed that the position of sulfonamide group in meta of the 1-phenylpyrazole increase a selectivity hCA IX versus hCA II of our compounds. An in vitro antiproliferative screening has been performed on the breast cancer MDA-MB-231 cell using doxorubicin as cytotoxic agent and in presence of selected CA IX inhibitor. The results shown that the cytotoxic efficiency of doxorubicin in an hypoxic environment, expressed in IC50 value, is restored at 20% level with 1 μM CA IX inhibitor." @default.
• W1995011648 created "2016-06-24" @default.
• W1995011648 creator A5008940287 @default.
• W1995011648 creator A5012797490 @default.
• W1995011648 creator A5012800657 @default.
• W1995011648 creator A5029204643 @default.
• W1995011648 creator A5033789467 @default.
• W1995011648 creator A5035013697 @default.
• W1995011648 creator A5044314125 @default.
• W1995011648 creator A5056075300 @default.
• W1995011648 creator A5067396861 @default.
• W1995011648 creator A5068731081 @default.
• W1995011648 creator A5069337254 @default.
• W1995011648 creator A5078990978 @default.
• W1995011648 creator A5081430054 @default.
• W1995011648 creator A5086670020 @default.
• W1995011648 creator A5091771182 @default.
• W1995011648 date "2013-03-01" @default.
• W1995011648 modified "2023-10-18" @default.
• W1995011648 title "New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides" @default.
• W1995011648 cites W1573899446 @default.
• W1995011648 cites W1964914233 @default.
• W1995011648 cites W1969694148 @default.
• W1995011648 cites W2010967562 @default.
• W1995011648 cites W2016853027 @default.
• W1995011648 cites W2025766128 @default.
• W1995011648 cites W2028855134 @default.
• W1995011648 cites W2041853813 @default.
• W1995011648 cites W2045359719 @default.
• W1995011648 cites W2047178318 @default.
• W1995011648 cites W2050456292 @default.
• W1995011648 cites W2051349300 @default.
• W1995011648 cites W2067704885 @default.
• W1995011648 cites W2077365401 @default.
• W1995011648 cites W2079310958 @default.
• W1995011648 cites W2084650789 @default.
• W1995011648 cites W2085193261 @default.
• W1995011648 cites W2088350865 @default.
• W1995011648 cites W2096733754 @default.
• W1995011648 cites W2101908524 @default.
• W1995011648 cites W2159783793 @default.
• W1995011648 cites W2507614417 @default.
• W1995011648 doi "https://doi.org/10.1016/j.bmc.2012.10.029" @default.
• W1995011648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23168081" @default.
• W1995011648 hasPublicationYear "2013" @default.
• W1995011648 type Work @default.
• W1995011648 sameAs 1995011648 @default.
• W1995011648 citedByCount "57" @default.
• W1995011648 countsByYear W19950116482013 @default.
• W1995011648 countsByYear W19950116482014 @default.
• W1995011648 countsByYear W19950116482015 @default.
• W1995011648 countsByYear W19950116482016 @default.
• W1995011648 countsByYear W19950116482017 @default.
• W1995011648 countsByYear W19950116482018 @default.
• W1995011648 countsByYear W19950116482019 @default.
• W1995011648 countsByYear W19950116482020 @default.
• W1995011648 countsByYear W19950116482021 @default.
• W1995011648 countsByYear W19950116482022 @default.
• W1995011648 countsByYear W19950116482023 @default.
• W1995011648 crossrefType "journal-article" @default.
• W1995011648 hasAuthorship W1995011648A5008940287 @default.
• W1995011648 hasAuthorship W1995011648A5012797490 @default.
• W1995011648 hasAuthorship W1995011648A5012800657 @default.
• W1995011648 hasAuthorship W1995011648A5029204643 @default.
• W1995011648 hasAuthorship W1995011648A5033789467 @default.
• W1995011648 hasAuthorship W1995011648A5035013697 @default.
• W1995011648 hasAuthorship W1995011648A5044314125 @default.
• W1995011648 hasAuthorship W1995011648A5056075300 @default.
• W1995011648 hasAuthorship W1995011648A5067396861 @default.
• W1995011648 hasAuthorship W1995011648A5068731081 @default.
• W1995011648 hasAuthorship W1995011648A5069337254 @default.
• W1995011648 hasAuthorship W1995011648A5078990978 @default.
• W1995011648 hasAuthorship W1995011648A5081430054 @default.
• W1995011648 hasAuthorship W1995011648A5086670020 @default.
• W1995011648 hasAuthorship W1995011648A5091771182 @default.
• W1995011648 hasConcept C109316439 @default.
• W1995011648 hasConcept C126322002 @default.
• W1995011648 hasConcept C154317977 @default.
• W1995011648 hasConcept C181199279 @default.
• W1995011648 hasConcept C185592680 @default.
• W1995011648 hasConcept C202751555 @default.
• W1995011648 hasConcept C2775914622 @default.
• W1995011648 hasConcept C2776694085 @default.
• W1995011648 hasConcept C2777752497 @default.
• W1995011648 hasConcept C2780416268 @default.
• W1995011648 hasConcept C2781039511 @default.
• W1995011648 hasConcept C2781303535 @default.
• W1995011648 hasConcept C55493867 @default.
• W1995011648 hasConcept C71240020 @default.
• W1995011648 hasConcept C71924100 @default.
• W1995011648 hasConcept C86803240 @default.
• W1995011648 hasConcept C98274493 @default.
• W1995011648 hasConceptScore W1995011648C109316439 @default.
• W1995011648 hasConceptScore W1995011648C126322002 @default.
• W1995011648 hasConceptScore W1995011648C154317977 @default.
• W1995011648 hasConceptScore W1995011648C181199279 @default.
• W1995011648 hasConceptScore W1995011648C185592680 @default.
• W1995011648 hasConceptScore W1995011648C202751555 @default.

• next