Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995015104> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1995015104 endingPage "334" @default.
- W1995015104 startingPage "329" @default.
- W1995015104 abstract "The aim of this study was to investigate whether the renoprotective effect of angiotensin–converting enzyme inhibitors (ACEIs) following 5/6 renal mass reduction is due in part to the potentiation of kinins. Three groups of rats with 5/6 renal mass reduction were studied during the 14 weeks following surgery. One group received no therapy (control); the second group was treated from the beginning with the ACEI ramipril (1 mg/kg/day) added to the drinking water, and the last group received ramipril plus a β<sub>2</sub>–bradykinin antagonist, HOE 140 (500 μg/kg/day) via osmotic minipumps. Plasma creatinine did not change in any group during the study. Urinary protein excretion rose in the controls from 9.18±1.6 to 45.0±5.6 mg/24 h at the end of the study. In ramipril group proteinuria was prevented (initial 7.5±1.0 and final 8.6±0.8 mg/24h). The effect of ramipril was abolished by HOE 140 (initial 11.6±2.0 and final 38.9±11 mg/ 24h). The systolic blood pressure of the controls increased from 106±2 to 144±5mmHg at the 14th week. Ramipril abolished the increase in systolic blood pressure. The effect of ramipril was reverted by HOE 140 (initial 108±2 and final 140±9 mmHg). Control rats had more severe histopathologic changes. Those animals receiving ramipril + HOE 140 displayed less severe glomerular changes, while rats treated only with ramipril had mild alterations. Thus the glomerular injury score was 2.11±0.32 for controls, 1.53±0.52 for rats treated with ramipril + HOE 140, and 0.06±0.04 for rats treated only with ramipril. The glomerular area was 20,886±1,410, 19,693±2,200 and 14,352±3,200 μm<sup>2</sup>, respectively, for the 3 groups. These results suggest that the protective effect of ACEIs in the development of chronic renal failure is partially mediated by kinins." @default.
- W1995015104 created "2016-06-24" @default.
- W1995015104 creator A5006585545 @default.
- W1995015104 creator A5041748529 @default.
- W1995015104 creator A5044437886 @default.
- W1995015104 creator A5045382153 @default.
- W1995015104 creator A5084000215 @default.
- W1995015104 date "1998-01-01" @default.
- W1995015104 modified "2023-09-25" @default.
- W1995015104 title "Role of Kinins in the Renoprotective Effect of Angiotensin–Converting Enzyme Inhibitors in Experimental Chronic Renal Failure" @default.
- W1995015104 cites W2021113931 @default.
- W1995015104 cites W2067349865 @default.
- W1995015104 doi "https://doi.org/10.1159/000025890" @default.
- W1995015104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9851320" @default.
- W1995015104 hasPublicationYear "1998" @default.
- W1995015104 type Work @default.
- W1995015104 sameAs 1995015104 @default.
- W1995015104 citedByCount "23" @default.
- W1995015104 countsByYear W19950151042012 @default.
- W1995015104 countsByYear W19950151042015 @default.
- W1995015104 countsByYear W19950151042016 @default.
- W1995015104 countsByYear W19950151042017 @default.
- W1995015104 crossrefType "journal-article" @default.
- W1995015104 hasAuthorship W1995015104A5006585545 @default.
- W1995015104 hasAuthorship W1995015104A5041748529 @default.
- W1995015104 hasAuthorship W1995015104A5044437886 @default.
- W1995015104 hasAuthorship W1995015104A5045382153 @default.
- W1995015104 hasAuthorship W1995015104A5084000215 @default.
- W1995015104 hasConcept C10146269 @default.
- W1995015104 hasConcept C126322002 @default.
- W1995015104 hasConcept C126894567 @default.
- W1995015104 hasConcept C134018914 @default.
- W1995015104 hasConcept C159641895 @default.
- W1995015104 hasConcept C170493617 @default.
- W1995015104 hasConcept C27016395 @default.
- W1995015104 hasConcept C2778211319 @default.
- W1995015104 hasConcept C2779561371 @default.
- W1995015104 hasConcept C2779591629 @default.
- W1995015104 hasConcept C2779611605 @default.
- W1995015104 hasConcept C2779888176 @default.
- W1995015104 hasConcept C2780091579 @default.
- W1995015104 hasConcept C2780306776 @default.
- W1995015104 hasConcept C71924100 @default.
- W1995015104 hasConcept C84393581 @default.
- W1995015104 hasConceptScore W1995015104C10146269 @default.
- W1995015104 hasConceptScore W1995015104C126322002 @default.
- W1995015104 hasConceptScore W1995015104C126894567 @default.
- W1995015104 hasConceptScore W1995015104C134018914 @default.
- W1995015104 hasConceptScore W1995015104C159641895 @default.
- W1995015104 hasConceptScore W1995015104C170493617 @default.
- W1995015104 hasConceptScore W1995015104C27016395 @default.
- W1995015104 hasConceptScore W1995015104C2778211319 @default.
- W1995015104 hasConceptScore W1995015104C2779561371 @default.
- W1995015104 hasConceptScore W1995015104C2779591629 @default.
- W1995015104 hasConceptScore W1995015104C2779611605 @default.
- W1995015104 hasConceptScore W1995015104C2779888176 @default.
- W1995015104 hasConceptScore W1995015104C2780091579 @default.
- W1995015104 hasConceptScore W1995015104C2780306776 @default.
- W1995015104 hasConceptScore W1995015104C71924100 @default.
- W1995015104 hasConceptScore W1995015104C84393581 @default.
- W1995015104 hasIssue "5" @default.
- W1995015104 hasLocation W19950151041 @default.
- W1995015104 hasLocation W19950151042 @default.
- W1995015104 hasOpenAccess W1995015104 @default.
- W1995015104 hasPrimaryLocation W19950151041 @default.
- W1995015104 hasRelatedWork W1996977299 @default.
- W1995015104 hasRelatedWork W2000915067 @default.
- W1995015104 hasRelatedWork W2041312552 @default.
- W1995015104 hasRelatedWork W2056181314 @default.
- W1995015104 hasRelatedWork W2057046353 @default.
- W1995015104 hasRelatedWork W2067424143 @default.
- W1995015104 hasRelatedWork W2138670606 @default.
- W1995015104 hasRelatedWork W2413014694 @default.
- W1995015104 hasRelatedWork W3195146163 @default.
- W1995015104 hasRelatedWork W4252042920 @default.
- W1995015104 hasVolume "21" @default.
- W1995015104 isParatext "false" @default.
- W1995015104 isRetracted "false" @default.
- W1995015104 magId "1995015104" @default.
- W1995015104 workType "article" @default.