FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995021820> ?p ?o ?g. }

• W1995021820 endingPage "320" @default.
• W1995021820 startingPage "312" @default.
• W1995021820 abstract "For the simultaneous assessment of in vitro carcinogenicity and mutagenicity of phytoestrogens, the abilities of 5 phytoestrogens, daidzein, genistein, biochanin A, prunetin, and coumestrol, to induce cell transformation and genetic effects were examined using the Syrian hamster embryo (SHE) cell model. Cellular growth was inhibited by all phytoestrogens in a concentration-related manner. The growth inhibitory effect of the compounds was ranked: genistein, prunetin > coumestrol > biochanin A > daidzein, which did not correspond to their apoptosis-inducing abilities. Morphological transformation in SHE cells was elicited by all phytoestrogens, except, prunetin. The transforming activities were ranked as follows: genistein > coumestrol > daidzein > biochanin A. Somatic mutations in SHE cells at the Na+/K+ ATPase and hprt loci were induced only by genistein, coumestrol, or daidzein. Chromosome aberrations were induced by genistein or coumestrol, and aneuploidy in the near diploid range was occurred by genistein or biochanin A. Genistein, biochanin A or daidzein induced DNA adduct formation in SHE cells with the abilities: genistein > biochanin A > daidzein. Prunetin was negative for any of these genetic endpoints. Our results provide evidence that genistein, coumestrol, daidzein and biochanin A induce cell transformation in SHE cells and that the transforming activities of these phytoestrogens correspond to at least 2 of the mutagenic effects by each phytoestrogen, i.e., gene mutations, chromosome aberrations, aneuploidy or DNA adduct formation, suggesting the possible involvement of mutagenicity in the initiation of phytoestrogen-induced carcinogenesis. © 2003 Wiley-Liss, Inc." @default.
• W1995021820 created "2016-06-24" @default.
• W1995021820 creator A5012766420 @default.
• W1995021820 creator A5020643249 @default.
• W1995021820 creator A5022983263 @default.
• W1995021820 creator A5033267044 @default.
• W1995021820 creator A5034958718 @default.
• W1995021820 creator A5045263771 @default.
• W1995021820 creator A5077925178 @default.
• W1995021820 date "2003-04-14" @default.
• W1995021820 modified "2023-10-17" @default.
• W1995021820 title "Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells" @default.
• W1995021820 cites W1935548307 @default.
• W1995021820 cites W1944310027 @default.
• W1995021820 cites W1969394610 @default.
• W1995021820 cites W1972560735 @default.
• W1995021820 cites W1988595385 @default.
• W1995021820 cites W1988666825 @default.
• W1995021820 cites W2009527950 @default.
• W1995021820 cites W2012019447 @default.
• W1995021820 cites W2019126131 @default.
• W1995021820 cites W2029080338 @default.
• W1995021820 cites W2035925517 @default.
• W1995021820 cites W2036203220 @default.
• W1995021820 cites W2037698292 @default.
• W1995021820 cites W2040759582 @default.
• W1995021820 cites W2047852342 @default.
• W1995021820 cites W2069701115 @default.
• W1995021820 cites W2073200876 @default.
• W1995021820 cites W2078947463 @default.
• W1995021820 cites W2081905187 @default.
• W1995021820 cites W2088629741 @default.
• W1995021820 cites W2114781822 @default.
• W1995021820 cites W2118603147 @default.
• W1995021820 cites W2120420354 @default.
• W1995021820 cites W2121426826 @default.
• W1995021820 cites W2128442121 @default.
• W1995021820 cites W2162859956 @default.
• W1995021820 doi "https://doi.org/10.1002/ijc.11046" @default.
• W1995021820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12704663" @default.
• W1995021820 hasPublicationYear "2003" @default.
• W1995021820 type Work @default.
• W1995021820 sameAs 1995021820 @default.
• W1995021820 citedByCount "33" @default.
• W1995021820 countsByYear W19950218202012 @default.
• W1995021820 countsByYear W19950218202013 @default.
• W1995021820 countsByYear W19950218202014 @default.
• W1995021820 countsByYear W19950218202015 @default.
• W1995021820 countsByYear W19950218202016 @default.
• W1995021820 countsByYear W19950218202017 @default.
• W1995021820 countsByYear W19950218202019 @default.
• W1995021820 countsByYear W19950218202020 @default.
• W1995021820 countsByYear W19950218202021 @default.
• W1995021820 countsByYear W19950218202022 @default.
• W1995021820 countsByYear W19950218202023 @default.
• W1995021820 crossrefType "journal-article" @default.
• W1995021820 hasAuthorship W1995021820A5012766420 @default.
• W1995021820 hasAuthorship W1995021820A5020643249 @default.
• W1995021820 hasAuthorship W1995021820A5022983263 @default.
• W1995021820 hasAuthorship W1995021820A5033267044 @default.
• W1995021820 hasAuthorship W1995021820A5034958718 @default.
• W1995021820 hasAuthorship W1995021820A5045263771 @default.
• W1995021820 hasAuthorship W1995021820A5077925178 @default.
• W1995021820 hasBestOaLocation W19950218201 @default.
• W1995021820 hasConcept C134018914 @default.
• W1995021820 hasConcept C185592680 @default.
• W1995021820 hasConcept C2777164284 @default.
• W1995021820 hasConcept C2778270713 @default.
• W1995021820 hasConcept C2778298627 @default.
• W1995021820 hasConcept C2778355148 @default.
• W1995021820 hasConcept C2778821405 @default.
• W1995021820 hasConcept C2779705811 @default.
• W1995021820 hasConcept C2780955279 @default.
• W1995021820 hasConcept C86803240 @default.
• W1995021820 hasConceptScore W1995021820C134018914 @default.
• W1995021820 hasConceptScore W1995021820C185592680 @default.
• W1995021820 hasConceptScore W1995021820C2777164284 @default.
• W1995021820 hasConceptScore W1995021820C2778270713 @default.
• W1995021820 hasConceptScore W1995021820C2778298627 @default.
• W1995021820 hasConceptScore W1995021820C2778355148 @default.
• W1995021820 hasConceptScore W1995021820C2778821405 @default.
• W1995021820 hasConceptScore W1995021820C2779705811 @default.
• W1995021820 hasConceptScore W1995021820C2780955279 @default.
• W1995021820 hasConceptScore W1995021820C86803240 @default.
• W1995021820 hasIssue "3" @default.
• W1995021820 hasLocation W19950218201 @default.
• W1995021820 hasLocation W19950218202 @default.
• W1995021820 hasOpenAccess W1995021820 @default.
• W1995021820 hasPrimaryLocation W19950218201 @default.
• W1995021820 hasRelatedWork W106242731 @default.
• W1995021820 hasRelatedWork W1964535481 @default.
• W1995021820 hasRelatedWork W1987163241 @default.
• W1995021820 hasRelatedWork W1995625053 @default.
• W1995021820 hasRelatedWork W2026963772 @default.
• W1995021820 hasRelatedWork W2126309715 @default.
• W1995021820 hasRelatedWork W2153090494 @default.
• W1995021820 hasRelatedWork W2359808796 @default.
• W1995021820 hasRelatedWork W2512104 @default.

• next