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• W1995048629 abstract "Antigen exposure via airway epithelia is often associated with a failure to prime or with the preferential priming of Th2 cells. We previously reported that the intranasal delivery of a Th1-inducing antigen promoted Th2-dominated responses, rather than the expected Th1 responses. Thus, we proposed that when pulmonary T cell priming is induced, the lung microenvironment might intrinsically favor the generation of Th2 types of responses. To establish a potential mechanism for such preferential priming, we examined the initial interactions between antigens and resident antigen-presenting cells (APCs) within the lung. We show that intranasally delivered antigens are preferentially taken up and can be presented to antigen-specific T cells by a resident population of CD11c(bright) APCs. Most of these antigen-loaded APCs remained within lung tissues, and migration into secondary lymphoid organs was not crucial for T cell priming to occur within the pulmonary tract. Furthermore, these pulmonary APCs demonstrated a marked expression of IL-6 and IL-10 within hours of antigen uptake, suggesting that resident tissue APCs have the capacity to promote Th2 T cell differentiation in situ." @default.
• W1995048629 created "2016-06-24" @default.
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• W1995048629 date "2002-11-15" @default.
• W1995048629 modified "2023-10-03" @default.
• W1995048629 title "Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ" @default.
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• W1995048629 doi "https://doi.org/10.1172/jci16109" @default.
• W1995048629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151814" @default.
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