FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995052365> ?p ?o ?g. }

• W1995052365 endingPage "6789" @default.
• W1995052365 startingPage "6789" @default.
• W1995052365 abstract "We report a one-pot synthesis of spherical gold nanoparticles (52–22 nm) and their capping with cefaclor, a second-generation antibiotic, without use of other chemicals. The differently sized gold nanoparticles were fabricated by controlling the rate of reduction of gold ions in aqueous solution by varying the reaction temperature (20–70 °C). The primary amine group of cefaclor acted as both the reducing and capping agent for the synthesis of gold nanoparticles leaving the β-lactam ring of cefaclor available for activity against microbes. Antimicrobial testing showed that cefaclor reduced gold nanoparticles have potent antimicrobial activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria as compared to cefaclor or gold nanoparticles alone. The minimum inhibition concentrations (MICs) of cefaclor reduced gold nanoparticles were 10 µg mL−1 and 100 µg mL−1 for S. aureus and E. coli respectively. The cefaclor reduced gold nanoparticles were further coated onto poly(ethyleneimine) (PEI) modified glass surfaces to obtain antimicrobial coatings suitable for biomedical applications and were tested against E. coli as an exemplar of activity. The antimicrobial coatings were very robust under adverse conditions (pH 3 and 10), inhibited the growth of E. coli on their surfaces, and could be used many times with retained activity. Results from a combined spectroscopic (FTIR) and microscopic study (AFM) suggest that the action of these novel particles is through the combined action of cefaclor inhibiting the synthesis of the peptidoglycan layer and gold nanoparticles generating “holes” in bacterial cell walls thereby increasing the permeability of the cell wall, resulting in the leakage of cell contents and eventually cell death." @default.
• W1995052365 created "2016-06-24" @default.
• W1995052365 creator A5051978401 @default.
• W1995052365 creator A5078432793 @default.
• W1995052365 creator A5088824044 @default.
• W1995052365 date "2010-01-01" @default.
• W1995052365 modified "2023-09-30" @default.
• W1995052365 title "Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings" @default.
• W1995052365 cites W1661219405 @default.
• W1995052365 cites W1873078071 @default.
• W1995052365 cites W1966177413 @default.
• W1995052365 cites W1969645755 @default.
• W1995052365 cites W1972775656 @default.
• W1995052365 cites W1973676402 @default.
• W1995052365 cites W1979884986 @default.
• W1995052365 cites W1980595924 @default.
• W1995052365 cites W1983229044 @default.
• W1995052365 cites W1984876496 @default.
• W1995052365 cites W1985135318 @default.
• W1995052365 cites W1985636218 @default.
• W1995052365 cites W1986286007 @default.
• W1995052365 cites W1986493115 @default.
• W1995052365 cites W1986806705 @default.
• W1995052365 cites W1989851529 @default.
• W1995052365 cites W1989985563 @default.
• W1995052365 cites W1999680644 @default.
• W1995052365 cites W2000678460 @default.
• W1995052365 cites W2001865610 @default.
• W1995052365 cites W2002661845 @default.
• W1995052365 cites W2006842594 @default.
• W1995052365 cites W2009421355 @default.
• W1995052365 cites W2009451079 @default.
• W1995052365 cites W2010477422 @default.
• W1995052365 cites W2011022279 @default.
• W1995052365 cites W2011817526 @default.
• W1995052365 cites W2014633697 @default.
• W1995052365 cites W2016483144 @default.
• W1995052365 cites W2021397153 @default.
• W1995052365 cites W2023705813 @default.
• W1995052365 cites W2024576504 @default.
• W1995052365 cites W2025934004 @default.
• W1995052365 cites W2026313972 @default.
• W1995052365 cites W2033717529 @default.
• W1995052365 cites W2035811471 @default.
• W1995052365 cites W2036670812 @default.
• W1995052365 cites W2038944974 @default.
• W1995052365 cites W2038968326 @default.
• W1995052365 cites W2046669455 @default.
• W1995052365 cites W2046890107 @default.
• W1995052365 cites W2047212216 @default.
• W1995052365 cites W2048247316 @default.
• W1995052365 cites W2053038159 @default.
• W1995052365 cites W2053303748 @default.
• W1995052365 cites W2054798334 @default.
• W1995052365 cites W2054997209 @default.
• W1995052365 cites W2056313363 @default.
• W1995052365 cites W2057509291 @default.
• W1995052365 cites W2058520941 @default.
• W1995052365 cites W2062646070 @default.
• W1995052365 cites W2063852310 @default.
• W1995052365 cites W2066112270 @default.
• W1995052365 cites W2075204249 @default.
• W1995052365 cites W2078143409 @default.
• W1995052365 cites W2082960348 @default.
• W1995052365 cites W2085889483 @default.
• W1995052365 cites W2087041160 @default.
• W1995052365 cites W2089546856 @default.
• W1995052365 cites W2104045947 @default.
• W1995052365 cites W2104062416 @default.
• W1995052365 cites W2112835254 @default.
• W1995052365 cites W2114012485 @default.
• W1995052365 cites W2114970456 @default.
• W1995052365 cites W2116067176 @default.
• W1995052365 cites W2116378268 @default.
• W1995052365 cites W2119115654 @default.
• W1995052365 cites W2126523540 @default.
• W1995052365 cites W2130022305 @default.
• W1995052365 cites W2134304198 @default.
• W1995052365 cites W2137838048 @default.
• W1995052365 cites W2139522201 @default.
• W1995052365 cites W2141001024 @default.
• W1995052365 cites W2144474172 @default.
• W1995052365 cites W2149780683 @default.
• W1995052365 cites W2151166188 @default.
• W1995052365 cites W2155385159 @default.
• W1995052365 cites W2160960872 @default.
• W1995052365 cites W2163716932 @default.
• W1995052365 cites W2164261054 @default.
• W1995052365 cites W2165044012 @default.
• W1995052365 cites W2169052499 @default.
• W1995052365 cites W2313771647 @default.
• W1995052365 cites W2324955110 @default.
• W1995052365 cites W2784717230 @default.
• W1995052365 cites W4241239017 @default.
• W1995052365 cites W4246179463 @default.
• W1995052365 cites W4247037143 @default.
• W1995052365 doi "https://doi.org/10.1039/c0jm00817f" @default.
• W1995052365 hasPublicationYear "2010" @default.

• next