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• W1995065889 abstract "We recently extended the classic flow–diffusion equation, which relates blood flow to tissue oxygenation, to take capillary transit time heterogeneity ( CTH) into account. Realizing that cerebral oxygen availability depends on both cerebral blood flow ( CBF) and capillary flow patterns, we have speculated that CTH may be actively regulated and that changes in the capillary morphology and function, as well as in blood rheology, may be involved in the pathogenesis of conditions such as dementia and ischemia-reperfusion injury. The first extended flow–diffusion equation involved simplifying assumptions which may not hold in tissue. Here, we explicitly incorporate the effects of oxygen metabolism on tissue oxygen tension and extraction efficacy, and assess the extent to which the type of capillary transit time distribution affects the overall effects of CTH on flow–metabolism coupling reported earlier. After incorporating tissue oxygen metabolism, our model predicts changes in oxygen consumption and tissue oxygen tension during functional activation in accordance with literature reports. We find that, for large CTH values, a blood flow increase fails to cause significant improvements in oxygen delivery, and can even decrease it; a condition of malignant CTH. These results are found to be largely insensitive to the choice of the transit time distribution." @default.
• W1995065889 created "2016-06-24" @default.
• W1995065889 creator A5031858487 @default.
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• W1995065889 date "2015-02-11" @default.
• W1995065889 modified "2023-10-13" @default.
• W1995065889 title "The Effects of Capillary Transit Time Heterogeneity (<i>CTH</i>) on Brain Oxygenation" @default.
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• W1995065889 doi "https://doi.org/10.1038/jcbfm.2014.254" @default.
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• W1995065889 hasPublicationYear "2015" @default.
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