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- W1995073915 abstract "These studies report the effect of overnight food deprivation on thromboxane production by mouse platelets stimulated with arachidonic acid. Phospholipase activity was also measured. We used radioimmunoassay to measure thromboxane B2 (TxB2) in platelet rich plasma (PRP) stimulated with 0.5 mM sodium arachidonate. TxB2 levels increased from 30 to 180 seconds after stimulation, and at 90 and 180 seconds were approximately twice as high in PRP from food deprived mice as compared with levels in PRP from fed animals (P<.01). The same period of food deprivation (17–21 hours) doubled the phospholipase A2 (PLA2) activity of the mouse platelets. No significant differences were observed between the TxB2 levels in PRP from normal mice and the PRP from mice with streptozotocin diabetes, although the marked elevation of TxB2 levels produced by food deprivation was somewhat greater in the PRP from diabetics. No differences were observed in PLA2 activity in diabetic as compared with control platelets. The marked enhancement of PLA2 activity produced by food deprivation, was seen in both control and diabetic platelets." @default.
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- W1995073915 date "1983-08-01" @default.
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- W1995073915 title "Overnight food deprivation in normal and diabetic mice markedly enhances thromboxane production by arachidonate stimulated platelet rich plasma and markedly increases platelet phospholipase A2 activity" @default.
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- W1995073915 doi "https://doi.org/10.1016/0049-3848(83)90453-x" @default.
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