FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995077216> ?p ?o ?g. }

• W1995077216 endingPage "91" @default.
• W1995077216 startingPage "85" @default.
• W1995077216 abstract "Crocetin, a carotenoid compound, was isolated from Gardenia jasminoids Ellis. Our recent study shows that crocetin inhibits angiotensin II-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation and subsequent proliferation in vascular smooth muscle cells (VSMCs). To further explore the mechanism involved, in the present study, we investigated the effect of Ca2+ in the activation of ERK1/2 and whether Ca2+ is involved in the suppression by crocetin of angiotensin II-induced ERK1/2 activation. Our findings showed that crocetin pretreatment partially attenuated both the intracellular Ca2+ mobilization and the extracellular Ca2+ influx induced by angiotensin II. Moreover, angiotensin II-induced ERK1/2 activation was completely abolished by acetoxymethyl ester of 1,2-bis(2-aminophenoxy)ethane-N,N,N ′,N′-tetraacetic acid (BAPTA-AM), an intracellular Ca2+ chelator, and partially inhibited by EGTA, an extracellular Ca2+ chelator, or verapamil, an L-type Ca2+ channel blocker. These findings suggest that Ca2+ may play an important role in angiotensin II-induced ERK1/2 activation in VSMCs, and Ca2+-dependent pathway may be involved in the inhibitory effect by crocetin of angiotensin II-induced ERK1/2 activation." @default.
• W1995077216 created "2016-06-24" @default.
• W1995077216 creator A5004493123 @default.
• W1995077216 creator A5010685909 @default.
• W1995077216 creator A5019559496 @default.
• W1995077216 creator A5070525459 @default.
• W1995077216 date "2007-01-01" @default.
• W1995077216 modified "2023-10-16" @default.
• W1995077216 title "Involvement of Ca2+ in the inhibition by crocetin of angiotensin II-induced ERK1/2 activation in vascular smooth muscle cells" @default.
• W1995077216 cites W1479814947 @default.
• W1995077216 cites W1573821584 @default.
• W1995077216 cites W1582350415 @default.
• W1995077216 cites W1863901809 @default.
• W1995077216 cites W1870773788 @default.
• W1995077216 cites W1889047426 @default.
• W1995077216 cites W1975479233 @default.
• W1995077216 cites W1980753124 @default.
• W1995077216 cites W1989226644 @default.
• W1995077216 cites W2002292023 @default.
• W1995077216 cites W2022792557 @default.
• W1995077216 cites W2027578116 @default.
• W1995077216 cites W2031089362 @default.
• W1995077216 cites W2053846349 @default.
• W1995077216 cites W2066696278 @default.
• W1995077216 cites W2068502127 @default.
• W1995077216 cites W2070023258 @default.
• W1995077216 cites W2078854095 @default.
• W1995077216 cites W2080999736 @default.
• W1995077216 cites W2082190322 @default.
• W1995077216 cites W2088505270 @default.
• W1995077216 cites W2092426681 @default.
• W1995077216 cites W2093725300 @default.
• W1995077216 cites W2094526206 @default.
• W1995077216 cites W2117312810 @default.
• W1995077216 cites W2123823383 @default.
• W1995077216 cites W2133691334 @default.
• W1995077216 cites W2142177362 @default.
• W1995077216 cites W2153761690 @default.
• W1995077216 cites W2153899018 @default.
• W1995077216 cites W2255671787 @default.
• W1995077216 cites W2321912463 @default.
• W1995077216 cites W4245279564 @default.
• W1995077216 doi "https://doi.org/10.1016/j.ejphar.2006.09.069" @default.
• W1995077216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17109849" @default.
• W1995077216 hasPublicationYear "2007" @default.
• W1995077216 type Work @default.
• W1995077216 sameAs 1995077216 @default.
• W1995077216 citedByCount "13" @default.
• W1995077216 countsByYear W19950772162013 @default.
• W1995077216 countsByYear W19950772162014 @default.
• W1995077216 countsByYear W19950772162016 @default.
• W1995077216 countsByYear W19950772162018 @default.
• W1995077216 countsByYear W19950772162019 @default.
• W1995077216 countsByYear W19950772162020 @default.
• W1995077216 crossrefType "journal-article" @default.
• W1995077216 hasAuthorship W1995077216A5004493123 @default.
• W1995077216 hasAuthorship W1995077216A5010685909 @default.
• W1995077216 hasAuthorship W1995077216A5019559496 @default.
• W1995077216 hasAuthorship W1995077216A5070525459 @default.
• W1995077216 hasConcept C134018914 @default.
• W1995077216 hasConcept C170493617 @default.
• W1995077216 hasConcept C178790620 @default.
• W1995077216 hasConcept C185592680 @default.
• W1995077216 hasConcept C2777022698 @default.
• W1995077216 hasConcept C2777658833 @default.
• W1995077216 hasConcept C2779395532 @default.
• W1995077216 hasConcept C2779900120 @default.
• W1995077216 hasConcept C28406088 @default.
• W1995077216 hasConcept C28781525 @default.
• W1995077216 hasConcept C2908929049 @default.
• W1995077216 hasConcept C2992686903 @default.
• W1995077216 hasConcept C519063684 @default.
• W1995077216 hasConcept C55493867 @default.
• W1995077216 hasConcept C79879829 @default.
• W1995077216 hasConcept C86803240 @default.
• W1995077216 hasConcept C98274493 @default.
• W1995077216 hasConceptScore W1995077216C134018914 @default.
• W1995077216 hasConceptScore W1995077216C170493617 @default.
• W1995077216 hasConceptScore W1995077216C178790620 @default.
• W1995077216 hasConceptScore W1995077216C185592680 @default.
• W1995077216 hasConceptScore W1995077216C2777022698 @default.
• W1995077216 hasConceptScore W1995077216C2777658833 @default.
• W1995077216 hasConceptScore W1995077216C2779395532 @default.
• W1995077216 hasConceptScore W1995077216C2779900120 @default.
• W1995077216 hasConceptScore W1995077216C28406088 @default.
• W1995077216 hasConceptScore W1995077216C28781525 @default.
• W1995077216 hasConceptScore W1995077216C2908929049 @default.
• W1995077216 hasConceptScore W1995077216C2992686903 @default.
• W1995077216 hasConceptScore W1995077216C519063684 @default.
• W1995077216 hasConceptScore W1995077216C55493867 @default.
• W1995077216 hasConceptScore W1995077216C79879829 @default.
• W1995077216 hasConceptScore W1995077216C86803240 @default.
• W1995077216 hasConceptScore W1995077216C98274493 @default.
• W1995077216 hasIssue "2-3" @default.
• W1995077216 hasLocation W19950772161 @default.
• W1995077216 hasOpenAccess W1995077216 @default.
• W1995077216 hasPrimaryLocation W19950772161 @default.
• W1995077216 hasRelatedWork W1966441338 @default.

• next