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• W1995084062 startingPage "384" @default.
• W1995084062 abstract "For more than 20 years, the gut has been hypothesized to be the motor of multiple organ dysfunction syndrome. As critical care research has evolved, there have been multiple mechanisms by which the gastrointestinal tract has been proposed to drive systemic inflammation. Many of these disparate mechanisms have proved to be important in the origin and propagation of critical illness. However, this has led to an unusual situation where investigators describing the gut as a motor revving the systemic inflammatory response syndrome are frequently describing wholly different processes to support their claim (i.e., increased apoptosis, altered tight junctions, translocation, cytokine production, crosstalk with commensal bacteria, etc). The purpose of this review is to present a unifying theory as to how the gut drives critical illness. Although the gastrointestinal tract is frequently described simply as the gut, it is actually made up of (1) an epithelium; (2) a diverse and robust immune arm, which contains most of the immune cells in the body; and (3) the commensal bacteria, which contain more cells than are present in the entire host organism. We propose that the intestinal epithelium, the intestinal immune system, and the intestine's endogenous bacteria all play vital roles driving multiple organ dysfunction syndrome, and the complex crosstalk between these three interrelated portions of the gastrointestinal tract is what cumulatively makes the gut a motor of critical illness." @default.
• W1995084062 created "2016-06-24" @default.
• W1995084062 creator A5012550644 @default.
• W1995084062 creator A5016493303 @default.
• W1995084062 date "2007-10-01" @default.
• W1995084062 modified "2023-10-04" @default.
• W1995084062 title "INTESTINAL CROSSTALK" @default.
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