Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995088897> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1995088897 endingPage "605" @default.
- W1995088897 startingPage "600" @default.
- W1995088897 abstract "Fyn is a Src-family tyrosine kinase involved in neuronal development, transmission, and plasticity in mammalian central nervous system. We have previously reported that Fyn binds to a cytoskeletal protein, β-adducin, in a phosphorylation-dependent manner. In the present report, we show that Fyn phosphorylates β-adducin at tyrosine 489 located in its C-terminal tail domain. Phosphorylation of β-adducin at Y489 was required for its association with the Fyn-SH2 domain. An antibody specific to the phosphorylated form of β-adducin was raised in rabbits and showed that Y489 of β-adducin was phosphorylated in wild type, but not in Fyn(−/−) mice, suggesting that Y489 of β-adducin is phosphorylated downstream of Fyn in vivo. After phosphorylation at Y489, β-adducin was translocated to the cell periphery, and colocalized with Fyn. These results suggest that Fyn phosphorylates and binds to β-adducin at Y489, resulting in translocation of β-adducin to the Fyn-enriched regions in the plasma membrane." @default.
- W1995088897 created "2016-06-24" @default.
- W1995088897 creator A5005875682 @default.
- W1995088897 creator A5017264724 @default.
- W1995088897 creator A5045663473 @default.
- W1995088897 creator A5067009952 @default.
- W1995088897 creator A5069356015 @default.
- W1995088897 creator A5077255722 @default.
- W1995088897 date "2006-07-01" @default.
- W1995088897 modified "2023-09-29" @default.
- W1995088897 title "Fyn-induced phosphorylation of β-adducin at tyrosine 489 and its role in their subcellular localization" @default.
- W1995088897 cites W1558538072 @default.
- W1995088897 cites W1582652395 @default.
- W1995088897 cites W1607929058 @default.
- W1995088897 cites W1979807697 @default.
- W1995088897 cites W2001953889 @default.
- W1995088897 cites W2005374323 @default.
- W1995088897 cites W2007733200 @default.
- W1995088897 cites W2009298846 @default.
- W1995088897 cites W2024137834 @default.
- W1995088897 cites W2028587304 @default.
- W1995088897 cites W2038424162 @default.
- W1995088897 cites W2042846734 @default.
- W1995088897 cites W2062227812 @default.
- W1995088897 cites W2080467864 @default.
- W1995088897 cites W2122882997 @default.
- W1995088897 cites W2164682544 @default.
- W1995088897 cites W2169584935 @default.
- W1995088897 cites W2320359118 @default.
- W1995088897 doi "https://doi.org/10.1016/j.bbrc.2006.05.167" @default.
- W1995088897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16765915" @default.
- W1995088897 hasPublicationYear "2006" @default.
- W1995088897 type Work @default.
- W1995088897 sameAs 1995088897 @default.
- W1995088897 citedByCount "18" @default.
- W1995088897 countsByYear W19950888972013 @default.
- W1995088897 countsByYear W19950888972014 @default.
- W1995088897 countsByYear W19950888972015 @default.
- W1995088897 countsByYear W19950888972017 @default.
- W1995088897 countsByYear W19950888972018 @default.
- W1995088897 countsByYear W19950888972023 @default.
- W1995088897 crossrefType "journal-article" @default.
- W1995088897 hasAuthorship W1995088897A5005875682 @default.
- W1995088897 hasAuthorship W1995088897A5017264724 @default.
- W1995088897 hasAuthorship W1995088897A5045663473 @default.
- W1995088897 hasAuthorship W1995088897A5067009952 @default.
- W1995088897 hasAuthorship W1995088897A5069356015 @default.
- W1995088897 hasAuthorship W1995088897A5077255722 @default.
- W1995088897 hasConcept C108636557 @default.
- W1995088897 hasConcept C11960822 @default.
- W1995088897 hasConcept C183141693 @default.
- W1995088897 hasConcept C197153747 @default.
- W1995088897 hasConcept C2776165026 @default.
- W1995088897 hasConcept C2777553839 @default.
- W1995088897 hasConcept C37686147 @default.
- W1995088897 hasConcept C42362537 @default.
- W1995088897 hasConcept C55493867 @default.
- W1995088897 hasConcept C62478195 @default.
- W1995088897 hasConcept C86803240 @default.
- W1995088897 hasConcept C95444343 @default.
- W1995088897 hasConceptScore W1995088897C108636557 @default.
- W1995088897 hasConceptScore W1995088897C11960822 @default.
- W1995088897 hasConceptScore W1995088897C183141693 @default.
- W1995088897 hasConceptScore W1995088897C197153747 @default.
- W1995088897 hasConceptScore W1995088897C2776165026 @default.
- W1995088897 hasConceptScore W1995088897C2777553839 @default.
- W1995088897 hasConceptScore W1995088897C37686147 @default.
- W1995088897 hasConceptScore W1995088897C42362537 @default.
- W1995088897 hasConceptScore W1995088897C55493867 @default.
- W1995088897 hasConceptScore W1995088897C62478195 @default.
- W1995088897 hasConceptScore W1995088897C86803240 @default.
- W1995088897 hasConceptScore W1995088897C95444343 @default.
- W1995088897 hasIssue "2" @default.
- W1995088897 hasLocation W19950888971 @default.
- W1995088897 hasLocation W19950888972 @default.
- W1995088897 hasOpenAccess W1995088897 @default.
- W1995088897 hasPrimaryLocation W19950888971 @default.
- W1995088897 hasRelatedWork W1731473784 @default.
- W1995088897 hasRelatedWork W1984701384 @default.
- W1995088897 hasRelatedWork W2027497451 @default.
- W1995088897 hasRelatedWork W2028613968 @default.
- W1995088897 hasRelatedWork W2090863009 @default.
- W1995088897 hasRelatedWork W2147554787 @default.
- W1995088897 hasRelatedWork W2157244708 @default.
- W1995088897 hasRelatedWork W4234331306 @default.
- W1995088897 hasRelatedWork W4242840686 @default.
- W1995088897 hasRelatedWork W87002874 @default.
- W1995088897 hasVolume "346" @default.
- W1995088897 isParatext "false" @default.
- W1995088897 isRetracted "false" @default.
- W1995088897 magId "1995088897" @default.
- W1995088897 workType "article" @default.