FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995091563> ?p ?o ?g. }

• W1995091563 endingPage "811" @default.
• W1995091563 startingPage "800" @default.
• W1995091563 abstract "The c-Jun-N-terminal kinase signaling pathway (JNK) is highly activated during ischemia and plays an important role in apoptosis and inflammation. We have previously demonstrated that D-JNKI1, a specific JNK inhibitor, is strongly neuroprotective in animal models of stroke. We presently evaluated if D-JNKI1 modulates post-ischemic inflammation such as the activation and accumulation of microglial cells. Outbred CD1 mice were subjected to 45 min middle cerebral artery occlusion (MCAo). D-JNKI1 (0.1 mg/kg) or vehicle (saline) was administered intravenously 3 h after MCAo onset. Lesion size at 48 h was significantly reduced, from 28.2 ± 8.5 mm3 (n = 7) to 13.9 ± 6.2 mm3 in the treated group (n = 6). Activation of the JNK pathway (phosphorylation of c-Jun) was observed in neurons as well as in Isolectin B4 positive microglia. We quantified activated microglia (CD11b) by measuring the average intensity of CD11b labelling (infra-red emission) within the ischemic tissue. No significant difference was found between groups. Cerebral ischemia was modelled in vitro by subjecting rat organotypic hippocampal slice cultures to oxygen (5%) and glucose deprivation for 30 min. In vitro, D-JNKI1 was found predominantly in NeuN positive neurons of the CA1 region and in few Isolectin B4 positive microglia. Furthermore, 48 h after OGD, microglia were activated whereas resting microglia were found in controls and in D-JNKI1-treated slices. Our study shows that D-JNKI1 reduces the infarct volume 48 h after transient MCAo and does not act on the activation and accumulation of microglia at this time point. In contrast, in vitro data show an indirect effect of D-JNKI1 on the modulation of microglial activation." @default.
• W1995091563 created "2016-06-24" @default.
• W1995091563 creator A5002023781 @default.
• W1995091563 creator A5043143732 @default.
• W1995091563 creator A5084034589 @default.
• W1995091563 date "2010-07-01" @default.
• W1995091563 modified "2023-09-25" @default.
• W1995091563 title "JNK inhibition and inflammation after cerebral ischemia" @default.
• W1995091563 cites W162287461 @default.
• W1995091563 cites W1773516416 @default.
• W1995091563 cites W1971668430 @default.
• W1995091563 cites W1977604451 @default.
• W1995091563 cites W1980478623 @default.
• W1995091563 cites W1980900081 @default.
• W1995091563 cites W1989255295 @default.
• W1995091563 cites W1990903837 @default.
• W1995091563 cites W1996443144 @default.
• W1995091563 cites W1997359311 @default.
• W1995091563 cites W1998721547 @default.
• W1995091563 cites W1999842143 @default.
• W1995091563 cites W2005509576 @default.
• W1995091563 cites W2006117395 @default.
• W1995091563 cites W2009191140 @default.
• W1995091563 cites W2012772303 @default.
• W1995091563 cites W2015182670 @default.
• W1995091563 cites W2019214426 @default.
• W1995091563 cites W2022378197 @default.
• W1995091563 cites W2034831207 @default.
• W1995091563 cites W2038438278 @default.
• W1995091563 cites W2040389813 @default.
• W1995091563 cites W2050985653 @default.
• W1995091563 cites W2059522164 @default.
• W1995091563 cites W2059995799 @default.
• W1995091563 cites W2065017488 @default.
• W1995091563 cites W2068210940 @default.
• W1995091563 cites W2076034559 @default.
• W1995091563 cites W2078779248 @default.
• W1995091563 cites W2087213531 @default.
• W1995091563 cites W2090804892 @default.
• W1995091563 cites W2094660330 @default.
• W1995091563 cites W2102935355 @default.
• W1995091563 cites W2106209450 @default.
• W1995091563 cites W2109759840 @default.
• W1995091563 cites W2125683177 @default.
• W1995091563 cites W2132189283 @default.
• W1995091563 cites W2138416324 @default.
• W1995091563 cites W2146346910 @default.
• W1995091563 cites W2150814283 @default.
• W1995091563 cites W2156488055 @default.
• W1995091563 cites W2160038308 @default.
• W1995091563 cites W2160974829 @default.
• W1995091563 cites W2169079203 @default.
• W1995091563 cites W3188111987 @default.
• W1995091563 cites W4210981518 @default.
• W1995091563 doi "https://doi.org/10.1016/j.bbi.2009.11.001" @default.
• W1995091563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19903520" @default.
• W1995091563 hasPublicationYear "2010" @default.
• W1995091563 type Work @default.
• W1995091563 sameAs 1995091563 @default.
• W1995091563 citedByCount "68" @default.
• W1995091563 countsByYear W19950915632012 @default.
• W1995091563 countsByYear W19950915632013 @default.
• W1995091563 countsByYear W19950915632014 @default.
• W1995091563 countsByYear W19950915632015 @default.
• W1995091563 countsByYear W19950915632016 @default.
• W1995091563 countsByYear W19950915632018 @default.
• W1995091563 countsByYear W19950915632019 @default.
• W1995091563 countsByYear W19950915632020 @default.
• W1995091563 countsByYear W19950915632021 @default.
• W1995091563 countsByYear W19950915632022 @default.
• W1995091563 countsByYear W19950915632023 @default.
• W1995091563 crossrefType "journal-article" @default.
• W1995091563 hasAuthorship W1995091563A5002023781 @default.
• W1995091563 hasAuthorship W1995091563A5043143732 @default.
• W1995091563 hasAuthorship W1995091563A5084034589 @default.
• W1995091563 hasConcept C126322002 @default.
• W1995091563 hasConcept C134018914 @default.
• W1995091563 hasConcept C148762608 @default.
• W1995091563 hasConcept C170493617 @default.
• W1995091563 hasConcept C171779818 @default.
• W1995091563 hasConcept C185592680 @default.
• W1995091563 hasConcept C190283241 @default.
• W1995091563 hasConcept C204232928 @default.
• W1995091563 hasConcept C25498285 @default.
• W1995091563 hasConcept C2776914184 @default.
• W1995091563 hasConcept C2779830541 @default.
• W1995091563 hasConcept C2781100881 @default.
• W1995091563 hasConcept C541997718 @default.
• W1995091563 hasConcept C55493867 @default.
• W1995091563 hasConcept C71924100 @default.
• W1995091563 hasConcept C98274493 @default.
• W1995091563 hasConceptScore W1995091563C126322002 @default.
• W1995091563 hasConceptScore W1995091563C134018914 @default.
• W1995091563 hasConceptScore W1995091563C148762608 @default.
• W1995091563 hasConceptScore W1995091563C170493617 @default.
• W1995091563 hasConceptScore W1995091563C171779818 @default.
• W1995091563 hasConceptScore W1995091563C185592680 @default.
• W1995091563 hasConceptScore W1995091563C190283241 @default.

• next