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- W1995091641 abstract "Orexin acts as an orexigenic factor for the regulation of appetite and rhythmicity in rodents. In goldfish, intracerebroventricular (ICV) administration of orexin A has been shown to affect not only food intake, but also locomotor activity. However, as there is still no information regarding the effect of orexin A on emotional behavior in goldfish, we investigated the effect of orexin A on psychomotor activity in this species. Intracerebroventricular administration of synthetic orexin A at 2 and 4 pmol/g body weight (BW) enhanced locomotor activity, and this enhancement by orexin A at 4 pmol/g BW was attenuated by treatment with the orexin receptor 1 antagonist, SB334867, at 10 pmol/g BW. Since intact goldfish prefer a black to a white background area, or the lower to the upper area of a tank, we used two types of preference tests (black/white and upper/lower tests) for measuring anxiety-like behavior in goldfish. Intracerebroventricular administration of orexin A at 4 pmol/g BW shortened the time spent in the white background area, and increased the time taken to move from the lower to the upper area. This action of orexin A mimicked that of the central-type benzodiazepine receptor inverse agonist, FG-7142 (an anxiogenic agent), at 4 pmol/g BW. The anxiogenic-like effect of orexin A was abolished by treatment with SB334867 at 10 pmol/g BW. These results indicate that orexin A potently affects psychomotor activity in goldfish." @default.
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- W1995091641 date "2014-07-01" @default.
- W1995091641 modified "2023-10-16" @default.
- W1995091641 title "Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus" @default.
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- W1995091641 doi "https://doi.org/10.1016/j.yhbeh.2014.06.004" @default.
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