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• W1995094023 abstract "To determine if the immunomodulatory effect of ketamine is relevant to its rapid antidepressant activity, cultured human astroglial cells were incubated with ketamine, cytokine mix, or both. At 24 h, ketamine dose-dependently (100–500 μM) decreased IL-6 and TNFα production and gene expression and, at clinically relevant concentration (100 μM), augmented IL-β release and gene expression in both unstimulated and cytokine-stimulated cells. In unstimulated cells, ketamine also increased IL-8 production and mRNA expression. The reduction in IL-6 mRNA was significant within 1 h in unstimulated cells and at 4 h after stimulation. Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNFα." @default.
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• W1995094023 date "2015-05-01" @default.
• W1995094023 modified "2023-10-17" @default.
• W1995094023 title "Immunomodulatory activity of ketamine in human astroglial A172 cells: Possible relevance to its rapid antidepressant activity" @default.
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• W1995094023 doi "https://doi.org/10.1016/j.jneuroim.2015.03.012" @default.
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