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• W1995095086 abstract "Depletion of intracellular free magnesium (Mgi) is a characteristic feature of insulin resistance in essential hypertension, but it is not clear to what extent low Mgi levels contribute to insulin resistance, result from it, or both. As insulin-like growth factor I (IGF-I) may improve insulin resistance, we investigated whether this peptide could similarly improve Mgi responsiveness to insulin in hypertension, and whether this effect was related to any direct IGF-I effect on Mgi. 31P-Nuclear magnetic resonance spectroscopy was used to measure Mgi in erythrocytes from 13 fasting normotensive and 10 essential hypertensive subjects before and 30, 60, and 120 min after incubation with a physiologically maximal dose of insulin (200μ U/mL) and with different doses of recombinant human IGF-I (0.1–100 nmol/L). In normotensive subjects, IGF-I elevated Mgi (P < 0.05) in a dose- and time-dependent fashion, as did insulin (P < 0.05). However, in hypertensive subjects, maximal Mgi responses to insulin, but not to IGF-I, were blunted [insulin, 163 ± 11 to 177 ± 10 μmol/L (P = NS); IGF-I, 164 ± 6 to 190 ± 11.7 μmol/L (P < 0.05)]. Furthermore, for insulin, but not for IGF-I, cellular Mgi responsiveness was closely and directly related to basal Mgi levels (insulin: r = 0.72; P< 0.01; IGF-I: r = 0.18; P = NS). Lastly, blunted Mgi responses to insulin could be reversed by preincubation of hypertensive cells with IGF-I. We conclude that 1) both IGF-I and insulin stimulate erythrocyte Mgi levels; 2) cellular Mgi responses to insulin, but not to IGF-I, depend on basal Mgi levels, i.e. the higher the Mgi the greater the sensitivity to insulin; and 3) IGF-I potentiates insulin-induced stimulation of Mgi at doses that themselves do not raise Mgi. These effects of IGF-I may underlie at least in part its ability to improve insulin sensitivity clinically. Together, these data support a role for IGF-I in cellular magnesium metabolism and emphasize the importance of magnesium as a determinant of insulin action." @default.
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• W1995095086 date "1998-12-01" @default.
• W1995095086 modified "2023-10-16" @default.
• W1995095086 title "Magnesium Responsiveness to Insulin and Insulin-Like Growth Factor I in Erythrocytes from Normotensive and Hypertensive Subjects" @default.
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• W1995095086 doi "https://doi.org/10.1210/jcem.83.12.5327" @default.
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