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• W1995097372 abstract "The plant-derived insecticide, alpha-terthienyl was prepared by synthesis as 3',4'-di[14C]-alpha-terthienyl for pharmacokinetic and metabolism studies. When administered orally to rats at a single dose of 50 mg/kg, excretion of the labelled material was maximal one day after administration and declined to no measurable quantities by day 4. Two metabolites [1,4-di(2'-thienyl)1,4-butadione and 2-2'-bithiophene-5-carboxylic acid] and trace quantities of the parent material were isolated from the urine and chemically identified. These represent the first metabolites of alpha-terthienyl identified. In pilot acute and subacute trials, unlabelled alpha-terthienyl was non-toxic when administered orally to rats as the ready to use formulation (0.1% active ingredient). The pure compound had an LD50 of 110 mg/kg when administered intraperitoneally to rats. The results suggest that there is considerable separation with respect to mosquito larvae and non-target mammal sensitivity." @default.
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• W1995097372 date "1995-09-01" @default.
• W1995097372 modified "2023-10-14" @default.
• W1995097372 title "Pharmacokinetics, Metabolism and Toxicity of the Plant-Derived Photoxin α-Terthienyl" @default.
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• W1995097372 doi "https://doi.org/10.1111/j.1600-0773.1995.tb01007.x" @default.
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