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- W1995111689 abstract "The formalin test assesses the behavioral response of an animal to minor tissue injury-induced pain. Opioid antinociception in this test has been suggested to depend largely on activation of kappa receptors but mu agonists are also potent in reducing pain behavior. The present study used the irreversible mu antagonist, beta-funaltrexamine (beta-FNA), to examine the role of mu receptor activation in this test. beta-FNA given intracranially 4 h before testing fully blocked the effects of morphine and attenuated the effects of ethylketocyclazocine and U50,488H. The results do not support a role for kappa receptors in antinociception in the formalin test. Instead, mu and, possibly, delta receptors are involved." @default.
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- W1995111689 creator A5040876235 @default.
- W1995111689 date "1990-12-01" @default.
- W1995111689 modified "2023-09-26" @default.
- W1995111689 title "β-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test" @default.
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- W1995111689 doi "https://doi.org/10.1016/0091-3057(90)90553-t" @default.
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