FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995118043> ?p ?o ?g. }

• W1995118043 endingPage "e61686" @default.
• W1995118043 startingPage "e61686" @default.
• W1995118043 abstract "Stochasticity in gene regulation has been characterized extensively, but how it affects cellular growth and fitness is less clear. We study the growth of E. coli cells as they shift from glucose to lactose metabolism, which is characterized by an obligatory growth arrest in bulk experiments that is termed the lag phase. Here, we follow the growth dynamics of individual cells at minute-resolution using a single-cell assay in a microfluidic device during this shift, while also monitoring lac expression. Mirroring the bulk results, the majority of cells displays a growth arrest upon glucose exhaustion, and resume when triggered by stochastic lac expression events. However, a significant fraction of cells maintains a high rate of elongation and displays no detectable growth lag during the shift. This ability to suppress the growth lag should provide important selective advantages when nutrients are scarce. Trajectories of individual cells display a highly non-linear relation between lac expression and growth, with only a fraction of fully induced levels being sufficient for achieving near maximal growth. A stochastic molecular model together with measured dependencies between nutrient concentration, lac expression level, and growth accurately reproduces the observed switching distributions. The results show that a growth arrest is not obligatory in the classic diauxic shift, and underscore that regulatory stochasticity ought to be considered in terms of its impact on growth and survival." @default.
• W1995118043 created "2016-06-24" @default.
• W1995118043 creator A5042378046 @default.
• W1995118043 creator A5045414992 @default.
• W1995118043 creator A5051081243 @default.
• W1995118043 creator A5059626541 @default.
• W1995118043 creator A5072157461 @default.
• W1995118043 creator A5083927592 @default.
• W1995118043 date "2013-04-30" @default.
• W1995118043 modified "2023-09-25" @default.
• W1995118043 title "Single-Cell Dynamics Reveals Sustained Growth during Diauxic Shifts" @default.
• W1995118043 cites W1488973062 @default.
• W1995118043 cites W1500616201 @default.
• W1995118043 cites W1506462986 @default.
• W1995118043 cites W1857439565 @default.
• W1995118043 cites W1865175546 @default.
• W1995118043 cites W1880468382 @default.
• W1995118043 cites W1939195520 @default.
• W1995118043 cites W1978182054 @default.
• W1995118043 cites W1986887287 @default.
• W1995118043 cites W1997057704 @default.
• W1995118043 cites W2004801113 @default.
• W1995118043 cites W2009253350 @default.
• W1995118043 cites W2022694949 @default.
• W1995118043 cites W2029051828 @default.
• W1995118043 cites W2031822229 @default.
• W1995118043 cites W2032619610 @default.
• W1995118043 cites W2040889971 @default.
• W1995118043 cites W2043487490 @default.
• W1995118043 cites W2044909461 @default.
• W1995118043 cites W2048596643 @default.
• W1995118043 cites W2057107775 @default.
• W1995118043 cites W2064483836 @default.
• W1995118043 cites W2068872007 @default.
• W1995118043 cites W2107333582 @default.
• W1995118043 cites W2107342968 @default.
• W1995118043 cites W2107974075 @default.
• W1995118043 cites W2108419658 @default.
• W1995118043 cites W2116137883 @default.
• W1995118043 cites W2126733261 @default.
• W1995118043 cites W2127366503 @default.
• W1995118043 cites W2127771683 @default.
• W1995118043 cites W2128313698 @default.
• W1995118043 cites W2129904447 @default.
• W1995118043 cites W2139500219 @default.
• W1995118043 cites W2144748567 @default.
• W1995118043 cites W2147488815 @default.
• W1995118043 cites W2148740882 @default.
• W1995118043 cites W2149242848 @default.
• W1995118043 cites W2155123192 @default.
• W1995118043 cites W2159443864 @default.
• W1995118043 cites W2164277408 @default.
• W1995118043 cites W2167900930 @default.
• W1995118043 cites W2171280873 @default.
• W1995118043 cites W2614283331 @default.
• W1995118043 cites W4233808990 @default.
• W1995118043 cites W4245882143 @default.
• W1995118043 cites W4246084803 @default.
• W1995118043 cites W4255988097 @default.
• W1995118043 doi "https://doi.org/10.1371/journal.pone.0061686" @default.
• W1995118043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640066" @default.
• W1995118043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637881" @default.
• W1995118043 hasPublicationYear "2013" @default.
• W1995118043 type Work @default.
• W1995118043 sameAs 1995118043 @default.
• W1995118043 citedByCount "82" @default.
• W1995118043 countsByYear W19951180432014 @default.
• W1995118043 countsByYear W19951180432015 @default.
• W1995118043 countsByYear W19951180432016 @default.
• W1995118043 countsByYear W19951180432017 @default.
• W1995118043 countsByYear W19951180432018 @default.
• W1995118043 countsByYear W19951180432019 @default.
• W1995118043 countsByYear W19951180432020 @default.
• W1995118043 countsByYear W19951180432021 @default.
• W1995118043 countsByYear W19951180432022 @default.
• W1995118043 countsByYear W19951180432023 @default.
• W1995118043 crossrefType "journal-article" @default.
• W1995118043 hasAuthorship W1995118043A5042378046 @default.
• W1995118043 hasAuthorship W1995118043A5045414992 @default.
• W1995118043 hasAuthorship W1995118043A5051081243 @default.
• W1995118043 hasAuthorship W1995118043A5059626541 @default.
• W1995118043 hasAuthorship W1995118043A5072157461 @default.
• W1995118043 hasAuthorship W1995118043A5083927592 @default.
• W1995118043 hasBestOaLocation W19951180431 @default.
• W1995118043 hasConcept C104317684 @default.
• W1995118043 hasConcept C121332964 @default.
• W1995118043 hasConcept C12554922 @default.
• W1995118043 hasConcept C145912823 @default.
• W1995118043 hasConcept C150194340 @default.
• W1995118043 hasConcept C170344550 @default.
• W1995118043 hasConcept C185592680 @default.
• W1995118043 hasConcept C24890656 @default.
• W1995118043 hasConcept C2524010 @default.
• W1995118043 hasConcept C2778312390 @default.
• W1995118043 hasConcept C31258907 @default.
• W1995118043 hasConcept C33923547 @default.
• W1995118043 hasConcept C41008148 @default.
• W1995118043 hasConcept C55493867 @default.

• next