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• W1995123485 abstract "1. Both lipolytic hormones (ACTH, epinephrine, glucagon) and ouabain were found to stimulate the uptake of glucose, the oxidation of glucose to CO2, and the total lipid synthesis from glucose in adipose cells. However, the ouabain-induced conversion of glucose to glyceride fatty acid was greater than that to glycerideglycerol, while the opposite is known to occur in the presence of lipolytic hormones. Furthermore, glycogenolysis was inhibited and glycogen synthesis stimulated by ouabain, again the opposite of what occurs with lipolytic hormones. 2. The effects of ouabain and of other antilipolytic agents, and those of lipolytic hormones were further compared, using as substrate glucose specifically labelled in the first ([1-14C]glucose) or in the sixth ([6-14C]glucose) position. The clearest differentiation of the metabolic action of these agents was obtained by calculating the ratios relating glyceride-glycerol (GG) to glyceride-fatty acids (GFA) for both [1-14C]-glucose and [6-14C]glucose (GG-1/GFA-1; GG-6/GFA-6); and the ratios of 14CO2 obtained from specifically labelled glucose (CO2-1/CO2-6). The pentose cycle activity was also estimated. 3. All antilipolytic agents tested (insulin, ouabain, 5-methylpyrazole-3-carboxylic acid, nicotinic acid) increased glucose metabolism through the pentose cycle. They all decreased the GG-1/GFA-1 and GG-6/GFA-6 ratios, while increasing the CO2-1/CO2-6 ratios. These effects could be mimicked by decreasing free fatty acid or increasing glucose concentrations in the medium. 4. All lipolytic agents tested (ACTH, epinephrine, dibutyryl-3',5'-AMP) decreased glucose metabolism through the pentose cycle. Their effect on the abovementioned ratios were exactly opposite to those observed with antilipolytic agents. Furthermore, these effects could be mimicked by increasing free fatty acid or lowering glucose concentrations in the medium. 5. The similarity between the action of ouabain and that of other antilipolytic agents suggests a close relationship between the effects on glucose metabolism and on lipolysis, both effects being probably related to the inhibitory effect of ouabain on electrolyte transport since they can also be induced by omitting K+ from the medium. 6. The results obtained in this study support the view that the antilipolytic agents which may be expected to decrease intracellular concentrations of free fatty acid exert similar effects upon the pattern of glucose metabolism. On the other hand, lipolytic agents, including dibutyril-3',5'-AMP, while they also stimulate the metabolism of glucose, produce a metabolic pattern clearly different from that of the antilipolytic agents. This pattern was similar for all of the agents which may be assumed to increase the intracellular level of free fatty acids. 7. Although these experiments support the likely importance of cyclic 3',5'-AMP in regulating metabolic processes in fat cells, the precise relationship between adenyl cyclase activity and glucose uptake is still unclear. It is conceivable that the intracellular free fatty acid levels within the adipocyte may represent an intermediate link resulting in the stimulation or inhibition of certain enzymatic activities, both secondarily increasing the uptake of glucose." @default.
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• W1995123485 date "1967-08-01" @default.
• W1995123485 modified "2023-09-24" @default.
• W1995123485 title "Insulin-like action of ouabain I. effect on carbohydrate metabolism" @default.
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• W1995123485 doi "https://doi.org/10.1016/0005-2760(67)90077-x" @default.
• W1995123485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4293398" @default.
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