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• W1995154411 abstract "Background: Renal sympathetic hyperactivity is seminal in the progression of hypertension (HTN). Catheter-based renal sympathetic denervation (RDN) has been shown to significantly reduce blood pressure in patients with hypertension (HTN). Durability of effect at 2-years using this novel technique has never been reported. Methods: A cohort of 45 patients with resistant HTN (SBP ≥160 mmHg on ≥3 anti-HTN drugs, including a diuretic) was originally reported in the Lancet. We report longer term data on these patients and similar patients subsequently treated with the catheter-based renal denervation in non-randomized studies. Office blood pressure (BP) data and safety data were available at 1, 3, 6, 12, 18 and 24 months post-procedure. eGFR at 3 and 12 months were available. Results: 117 pts were treated with catheter-based RDN at 17 centers in Australia, Europe, and the US. Mean age was 57±11 yrs, 40% were female, 33% diabetic, 22% with CAD. Baseline values include mean office BP 176/98 ± 17/14 mmHg, mean of 5.0 anti-HTN medications, and eGFR 82 ± 19 mL/min. The procedure lasted a median of 38 minutes. Four acute procedural complications occurred: three groin pseudoaneurysms and one renal artery dissection, all managed without further sequelae. Post-procedure office BPs were reduced by 20/11, 24/10, 24/12, 25/12, 29/17, and 33/14 mmHg at 1, 3, 6, 12, 18, and 24 months respectively. At 3-months the eGFR had changed by -1.4 mL/min (95% CI: -4.6 to 1.7), and at 12-months the eGFR had changed by -2.8 mL/min (95% CI: -6.4 to 0.8). One patient required stenting of a renal artery ostial stenosis that was present at baseline but grew by 6 months; no radiofrequency energy had been delivered in this location. Otherwise, there were no late adverse events associated with the therapy. Conclusions: Catheter-based RDN results in a substantial reduction in BP sustained to at least 2 years, without significant adverse events, in patients with resistant HTN. The changes in eGFR are better than the natural history reported in similar patients." @default.
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• W1995154411 date "2010-06-01" @default.
• W1995154411 modified "2023-09-26" @default.
• W1995154411 title "TWO-YEAR DURABILITY OF BLOOD PRESSURE REDUCTION WITH CATHETER-BASED RENAL SYMPATHETIC DENERVATION: HT.3.04" @default.
• W1995154411 doi "https://doi.org/10.1097/01.hjh.0000379536.30499.40" @default.
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