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- W1995156778 abstract "Alveolar macrophage (AM) production of pro-inflammatory cytokines has been associated with the development of acute and chronic lung injury. However, the role of AM-derived IL·1Β in the development of bronchopulmonary dysplasia has not been extensively examined. To determine if in vitro production of IL-1Β by AM is influenced by maturity, cells were isolated by lung lavage from litters of newborn rabbits and from adults. After overnight incubation in serum-supplemented medium, newborn AM produced more IL-1Β than cells from adults. When these AM were then exposed for 2 h to endotoxin in serum-free medium, adult cells increased their IL-1Β secretion while the newborn cells did not. Newborn AM IL-1Β response to LPS returned by 24 h. AM from newborn rabbits also demonstrated increased spontaneous production and increased LPS-induced production of IL-1Β during overnight incubation in serum-free medium. The newborn rabbit AM appears to be up-regulated in its IL·1Β production compared to the adult." @default.
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- W1995156778 date "1994-01-01" @default.
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- W1995156778 title "Elevated Production of lnterleukin-1-Beta from Alveolar Macrophages Isolated from Newborn Rabbits" @default.
- W1995156778 doi "https://doi.org/10.1159/000244095" @default.
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