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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995167631> ?p ?o ?g. }

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• W1995167631 abstract "The high molecular weight genomic DNA from 31 patients with idiopathic membranous nephropathy (IMN) has been digested with a restriction endonuclease Taq I, electrophoresed, blotted and hybridised with probes to the HLA-DRB, -DQA, -DQB, -DPA and -DPB genes. The restriction endonuclease Msp I was also used with the HLA-DPA and -DPB probes. The resulting restriction fragment length polymorphism (RFLP) has been analysed and compared with 55 controls treated in the same way. There was a significant increase in the DRB restriction fragments associated with HLA-DR3 (Fisher's p = 0.011), in particular with a sub-division of DR3 (Fisher's p = 0.0038). These results confirm at the DNA level serological correlations observed for IMN. A 4.5 Kb DQA RFLP was significantly raised in IMN patients (Fisher's p = 0.0002) and is proposed as a major disease susceptibility factor." @default.
• W1995167631 created "2016-06-24" @default.
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• W1995167631 date "1989-11-01" @default.
• W1995167631 modified "2023-09-24" @default.
• W1995167631 title "A DQA1 allele is strongly associated with idiopathic membranous nephropathy" @default.
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• W1995167631 doi "https://doi.org/10.1111/j.1399-0039.1989.tb01741.x" @default.
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