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- W1995175027 abstract "An inversion of chromosome 14 present in the tumor cells of a patient with childhood acute lymphoblastic leukemia of B-cell lineage was shown to be the result of a site-specific recombination event between an immunoglobulin heavy-chain variable gene and the joining segment of a T-cell receptor alpha chain. This rearrangement resulted in the formation of a hybrid gene, part immunoglobulin and part T-cell receptor. Furthermore, this hybrid gene was transcribed into messenger RNA with a completely open reading frame. Thus, two loci felt to be normally activated at distinct and disparate points in lymphocyte development were unified and expressed in this tumor." @default.
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- W1995175027 date "1986-10-10" @default.
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- W1995175027 title "Common Mechanism of Chromosome Inversion in B- and T-Cell Tumors: Relevance to Lymphoid Development" @default.
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- W1995175027 doi "https://doi.org/10.1126/science.3092355" @default.
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