FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995175045> ?p ?o ?g. }

• W1995175045 endingPage "1909" @default.
• W1995175045 startingPage "1902" @default.
• W1995175045 abstract "Abstract The normal expression pattern of HMGA2, an architectural transcription factor, is primarily restricted to cells of the developing mesenchyme before their overt differentiation during organogenesis. A detailed in situ hybridization analysis showed that the undifferentiated mesoderm of the embryonic lung expressed Hmga2 but it was not expressed in the newborn or adult lung. Previously, HMGA2 was shown to be misexpressed in a number of benign, differentiated mesenchymal tumors including lipomas, uterine leiomyomas, and pulmonary chondroid hamartomas. Here, we show that HMGA2 is misexpressed in pulmonary lymphangiomyomatosis (LAM), a severe disorder of unknown etiology consisting of lymphatic smooth muscle cell proliferation that results in the obstruction of airways, lymphatics, and vessels. Immunohistochemistry was done with antibodies to HMGA2 and revealed expression in lung tissue samples obtained from 21 patients with LAM. In contrast, HMGA2 was not expressed in sections of normal adult lung or other proliferative interstitial lung diseases, indicating that the expression of HMGA2 in LAM represents aberrant gene activation and is not due solely to an increase in cellular proliferation. In vivo studies in transgenic mice show that misexpression of HMGA2 in smooth muscle cells resulted in increased proliferation of these cells in the lung surrounding the epithelial cells. Therefore, similar to the other mesenchymal neoplasms, HMGA2 misexpression in the smooth muscle cell leads to abnormal proliferation and LAM tumorigenesis. These results suggest that HMGA2 plays a central role in the pathogenesis of LAM and is a potential candidate as a therapeutic target. [Cancer Res 2007;67(5):1902–9]" @default.
• W1995175045 created "2016-06-24" @default.
• W1995175045 creator A5013741381 @default.
• W1995175045 creator A5014520801 @default.
• W1995175045 creator A5014926969 @default.
• W1995175045 creator A5019334319 @default.
• W1995175045 creator A5039442833 @default.
• W1995175045 creator A5041235770 @default.
• W1995175045 creator A5042744678 @default.
• W1995175045 creator A5052743109 @default.
• W1995175045 creator A5060496678 @default.
• W1995175045 creator A5060963552 @default.
• W1995175045 creator A5068265723 @default.
• W1995175045 creator A5090312838 @default.
• W1995175045 creator A5091728899 @default.
• W1995175045 date "2007-03-01" @default.
• W1995175045 modified "2023-10-17" @default.
• W1995175045 title "Identification of the Benign Mesenchymal Tumor Gene <i>HMGA2</i> in Lymphangiomyomatosis" @default.
• W1995175045 cites W1963522835 @default.
• W1995175045 cites W1963672516 @default.
• W1995175045 cites W1974031153 @default.
• W1995175045 cites W1984514547 @default.
• W1995175045 cites W1985530882 @default.
• W1995175045 cites W1992258392 @default.
• W1995175045 cites W2000892937 @default.
• W1995175045 cites W2002196322 @default.
• W1995175045 cites W2007515109 @default.
• W1995175045 cites W2012315992 @default.
• W1995175045 cites W2014703440 @default.
• W1995175045 cites W2016236490 @default.
• W1995175045 cites W2019630675 @default.
• W1995175045 cites W2020084263 @default.
• W1995175045 cites W2024175375 @default.
• W1995175045 cites W2030959219 @default.
• W1995175045 cites W2031650264 @default.
• W1995175045 cites W2038028072 @default.
• W1995175045 cites W2039616467 @default.
• W1995175045 cites W2041811289 @default.
• W1995175045 cites W2043789254 @default.
• W1995175045 cites W2061181595 @default.
• W1995175045 cites W2062995291 @default.
• W1995175045 cites W2063927773 @default.
• W1995175045 cites W2066807289 @default.
• W1995175045 cites W2072320859 @default.
• W1995175045 cites W2077522322 @default.
• W1995175045 cites W2078544216 @default.
• W1995175045 cites W2082420648 @default.
• W1995175045 cites W2086934839 @default.
• W1995175045 cites W2094049001 @default.
• W1995175045 cites W2100615474 @default.
• W1995175045 cites W2130937302 @default.
• W1995175045 cites W2140923971 @default.
• W1995175045 cites W2150620887 @default.
• W1995175045 cites W2165564343 @default.
• W1995175045 cites W4238356169 @default.
• W1995175045 cites W4249631129 @default.
• W1995175045 cites W51042709 @default.
• W1995175045 doi "https://doi.org/10.1158/0008-5472.can-06-1122" @default.
• W1995175045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17332316" @default.
• W1995175045 hasPublicationYear "2007" @default.
• W1995175045 type Work @default.
• W1995175045 sameAs 1995175045 @default.
• W1995175045 citedByCount "18" @default.
• W1995175045 countsByYear W19951750452012 @default.
• W1995175045 countsByYear W19951750452015 @default.
• W1995175045 countsByYear W19951750452016 @default.
• W1995175045 countsByYear W19951750452018 @default.
• W1995175045 countsByYear W19951750452019 @default.
• W1995175045 countsByYear W19951750452020 @default.
• W1995175045 countsByYear W19951750452021 @default.
• W1995175045 countsByYear W19951750452022 @default.
• W1995175045 crossrefType "journal-article" @default.
• W1995175045 hasAuthorship W1995175045A5013741381 @default.
• W1995175045 hasAuthorship W1995175045A5014520801 @default.
• W1995175045 hasAuthorship W1995175045A5014926969 @default.
• W1995175045 hasAuthorship W1995175045A5019334319 @default.
• W1995175045 hasAuthorship W1995175045A5039442833 @default.
• W1995175045 hasAuthorship W1995175045A5041235770 @default.
• W1995175045 hasAuthorship W1995175045A5042744678 @default.
• W1995175045 hasAuthorship W1995175045A5052743109 @default.
• W1995175045 hasAuthorship W1995175045A5060496678 @default.
• W1995175045 hasAuthorship W1995175045A5060963552 @default.
• W1995175045 hasAuthorship W1995175045A5068265723 @default.
• W1995175045 hasAuthorship W1995175045A5090312838 @default.
• W1995175045 hasAuthorship W1995175045A5091728899 @default.
• W1995175045 hasConcept C104317684 @default.
• W1995175045 hasConcept C121608353 @default.
• W1995175045 hasConcept C142724271 @default.
• W1995175045 hasConcept C145059251 @default.
• W1995175045 hasConcept C150194340 @default.
• W1995175045 hasConcept C198826908 @default.
• W1995175045 hasConcept C2529059 @default.
• W1995175045 hasConcept C2776340970 @default.
• W1995175045 hasConcept C502942594 @default.
• W1995175045 hasConcept C54355233 @default.
• W1995175045 hasConcept C55493867 @default.
• W1995175045 hasConcept C555283112 @default.
• W1995175045 hasConcept C71924100 @default.

• next