FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995175940> ?p ?o ?g. }

• W1995175940 endingPage "349" @default.
• W1995175940 startingPage "339" @default.
• W1995175940 abstract "Integration, an indispensable step for retrovirus replication, is executed by integrase (IN), which is expressed as a part of a Gag-Pol precursor. Although mechanistic detail of the IN-catalyzed integration reaction is well defined, numerous evidence have demonstrated that IN is involved in multiple steps of retrovirus replication other than integration. In this study, Huwe1, a HECT-type E3 ubiquitin ligase, was identified as a new cellular interactor of human immunodeficiency virus type 1 (HIV-1) IN. The interaction was mediated through the catalytic core domain of IN and a wide-range region of Huwe1. Interestingly, although depletion of Huwe1 in target cells did not affect the early phase of HIV-1 infection in a human T cell line, we found that infectivity of HIV-1 released from the Huwe1 knockdown cells was significantly augmented more than that of virus produced from control cells. The increase in infectivity occurred in proviral DNA synthesis. Further analysis revealed that Huwe1 interacted with HIV-1 Gag-Pol precursor protein through an IN domain. Our results suggest that Huwe1 in HIV-1 producer cells has a negative impact on early post-entry events during the next round of virus infection via association with an IN region of Gag-Pol." @default.
• W1995175940 created "2016-06-24" @default.
• W1995175940 creator A5001374645 @default.
• W1995175940 creator A5008431013 @default.
• W1995175940 creator A5012789660 @default.
• W1995175940 creator A5017237442 @default.
• W1995175940 creator A5021805587 @default.
• W1995175940 creator A5022697881 @default.
• W1995175940 creator A5067576791 @default.
• W1995175940 creator A5068637876 @default.
• W1995175940 creator A5080909064 @default.
• W1995175940 date "2011-04-01" @default.
• W1995175940 modified "2023-10-18" @default.
• W1995175940 title "Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity" @default.
• W1995175940 cites W1539825989 @default.
• W1995175940 cites W1546094383 @default.
• W1995175940 cites W1564861448 @default.
• W1995175940 cites W1591356060 @default.
• W1995175940 cites W1595803962 @default.
• W1995175940 cites W1599175475 @default.
• W1995175940 cites W1804821915 @default.
• W1995175940 cites W1969331835 @default.
• W1995175940 cites W1977135599 @default.
• W1995175940 cites W1983717909 @default.
• W1995175940 cites W1985087864 @default.
• W1995175940 cites W1985700039 @default.
• W1995175940 cites W1996789884 @default.
• W1995175940 cites W2002381405 @default.
• W1995175940 cites W2005104278 @default.
• W1995175940 cites W2009382828 @default.
• W1995175940 cites W2010458160 @default.
• W1995175940 cites W2019508559 @default.
• W1995175940 cites W2041126567 @default.
• W1995175940 cites W2052373571 @default.
• W1995175940 cites W2054595210 @default.
• W1995175940 cites W2054612131 @default.
• W1995175940 cites W2062547838 @default.
• W1995175940 cites W2062821203 @default.
• W1995175940 cites W2063413156 @default.
• W1995175940 cites W2064139729 @default.
• W1995175940 cites W2067343115 @default.
• W1995175940 cites W2068749491 @default.
• W1995175940 cites W2076411120 @default.
• W1995175940 cites W2078061657 @default.
• W1995175940 cites W2078224183 @default.
• W1995175940 cites W2096955783 @default.
• W1995175940 cites W2107414760 @default.
• W1995175940 cites W2119629835 @default.
• W1995175940 cites W2124660271 @default.
• W1995175940 cites W2127697961 @default.
• W1995175940 cites W2144101850 @default.
• W1995175940 cites W2145848202 @default.
• W1995175940 cites W2146478787 @default.
• W1995175940 cites W2146667353 @default.
• W1995175940 cites W2148634265 @default.
• W1995175940 cites W2152581216 @default.
• W1995175940 cites W2161534592 @default.
• W1995175940 cites W2166420278 @default.
• W1995175940 doi "https://doi.org/10.1016/j.micinf.2010.12.002" @default.
• W1995175940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167302" @default.
• W1995175940 hasPublicationYear "2011" @default.
• W1995175940 type Work @default.
• W1995175940 sameAs 1995175940 @default.
• W1995175940 citedByCount "13" @default.
• W1995175940 countsByYear W19951759402012 @default.
• W1995175940 countsByYear W19951759402013 @default.
• W1995175940 countsByYear W19951759402015 @default.
• W1995175940 countsByYear W19951759402018 @default.
• W1995175940 countsByYear W19951759402020 @default.
• W1995175940 countsByYear W19951759402021 @default.
• W1995175940 countsByYear W19951759402022 @default.
• W1995175940 crossrefType "journal-article" @default.
• W1995175940 hasAuthorship W1995175940A5001374645 @default.
• W1995175940 hasAuthorship W1995175940A5008431013 @default.
• W1995175940 hasAuthorship W1995175940A5012789660 @default.
• W1995175940 hasAuthorship W1995175940A5017237442 @default.
• W1995175940 hasAuthorship W1995175940A5021805587 @default.
• W1995175940 hasAuthorship W1995175940A5022697881 @default.
• W1995175940 hasAuthorship W1995175940A5067576791 @default.
• W1995175940 hasAuthorship W1995175940A5068637876 @default.
• W1995175940 hasAuthorship W1995175940A5080909064 @default.
• W1995175940 hasConcept C104317684 @default.
• W1995175940 hasConcept C106358424 @default.
• W1995175940 hasConcept C134459356 @default.
• W1995175940 hasConcept C140704245 @default.
• W1995175940 hasConcept C14430832 @default.
• W1995175940 hasConcept C159047783 @default.
• W1995175940 hasConcept C2522874641 @default.
• W1995175940 hasConcept C25602115 @default.
• W1995175940 hasConcept C2778431562 @default.
• W1995175940 hasConcept C2781310106 @default.
• W1995175940 hasConcept C3013748606 @default.
• W1995175940 hasConcept C54355233 @default.
• W1995175940 hasConcept C86803240 @default.
• W1995175940 hasConcept C95444343 @default.
• W1995175940 hasConceptScore W1995175940C104317684 @default.
• W1995175940 hasConceptScore W1995175940C106358424 @default.
• W1995175940 hasConceptScore W1995175940C134459356 @default.

• next