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- W1995184413 abstract "The development of tryptophan hydroxylase in a number of regions of the midbrain and hindbrain of the chicken has been examined. In general, specific activities were low prior to day 14 of incubation of eggs. reaching a plateau around hatching (day 21). The total amount of tryptophan hydroxylase in the hindbrain, but not the midbrain. continued to increase after hatching. The injection of the dopamine antagonists haloperidol, ( + )-butaclamol, fluphenazine and methiothepin into the air sac of chicken eggs incubated for 14 days resulted in elevated levels of tryptophan hydroxylase in the hindbrain I region of 7-day-old chickens. With haloperidol. enzyme levels were higher in most regions of the midbrain and hindbrain, whereas with pimozide, the level of tryptophan hydroxylase decreased in the hindbrain I region, but not in other brain regions. The effect of haloperidol was on the development of tryptophan hydroxylase since it was without effect when injected into 7-day-old chickens and the levels of the enzyme measured 2 weeks later. Treatment of eggs with the dopamine agonists apomorphine. piribedil and S584. the serotonin antagonists methysergide and cyproheptadine, p-chloroamphetamine and dl-propranolol were without significant effect in any brain region examined." @default.
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- W1995184413 date "1979-03-01" @default.
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- W1995184413 title "The development of tryptophan hydroxylase in the chicken brain: Effects of p-chloroamphetamine and antagonists of serotonin, noradrenaline and dopamine" @default.
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- W1995184413 doi "https://doi.org/10.1016/0028-3908(79)90125-4" @default.
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