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- W1995190622 abstract "Plasma HIV-1 RNA measurements are used for initiation of antiretroviral treatments. Whether the viral-load association with prognosis is similar in women and men is unknown.We studied 812 specimens from 650 injection-drug users (IDUs) participating in a continuous observational study of patients based in a community clinic. HIV-1 load was measured by branched-chain DNA on samples from 527 IDUs from the baseline visit, and by reverse-transcriptase PCR and quantitative microculture on samples from 285 IDUs at a follow-up visit 3 years later.Women had lower median viral-load measurements than men by branched-chain DNA (3365 vs 8907 copies/mL; p=0·001), reverse-transcriptase PCR (45416 vs 93 130 copies/mL; p=0·02), and quantitative microculture (5 vs 8 infectious units per million peripheral blood mononuclear cells; p=0·015). This association remained even after adjustment for CD4 cell count, race, and drug use within the previous 6 months. Time to AIDS was statistically similar for men and women in a univariate proportional-hazards model and in a model adjusting for CD4 cell count. Proportional-hazards models showed that women with the same viral load as men had a 1·6-fold higher risk of AIDS (95% Cl 1·10-2·32); or, equivalently, that women with half the viral load of men had a similar time to AIDS as men.Although a biological mechanism remains unclear, these data suggest that current recommendations for HIV-1 viral-load thresholds to initiate antiretroviral therapy should be revised downwards for women." @default.
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- W1995190622 date "1995-10-01" @default.
- W1995190622 modified "2023-09-25" @default.
- W1995190622 title "A mathematical model for the prediction of the impact of HIV infection on tuberculosis" @default.
- W1995190622 doi "https://doi.org/10.1016/0962-8479(95)90041-1" @default.
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