FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995194331> ?p ?o ?g. }

• W1995194331 endingPage "116" @default.
• W1995194331 startingPage "110" @default.
• W1995194331 abstract "To establish phenotype-genotype correlations in early-onset Parkinson disease (EOPD), we performed neurologic, neuropsychological, and psychiatric evaluations in a series of patients with and without parkin mutations.Parkin (PARK2) gene mutations are the major cause of autosomal recessive parkinsonism. The usual clinical features are early-onset typical PD with a slow clinical course, an excellent response to low doses of levodopa, frequent treatment-induced dyskinesias, and the absence of dementia.A total of 44 patients with EOPD (21 with and 23 without parkin mutations) and 9 unaffected single heterozygous carriers of parkin mutations underwent extensive clinical, neuropsychological, and psychiatric examinations.The neurologic, neuropsychological, and psychiatric features were similar in all patients, except for significantly lower daily doses of dopaminergic treatment and greater delay in the development of levodopa-related fluctuations (p < 0.05) in parkin mutation carriers compared to noncarriers. There was no major difference between the two groups in terms of general cognitive efficiency. Psychiatric manifestations (depression) were more frequent in patients than in healthy single heterozygous parkin carriers but did not differ between the two groups of patients.Carriers of parkin mutations are clinically indistinguishable from other patients with young-onset Parkinson disease (PD) on an individual basis. Severe generalized loss of dopaminergic neurons in the substantia nigra pars compacta in these patients is associated with an excellent response to low doses of dopa-equivalent and delayed fluctuations, but cognitive impairment and special behavioral or psychiatric symptoms were not more severe than in other patients with early-onset PD." @default.
• W1995194331 created "2016-06-24" @default.
• W1995194331 creator A5001020863 @default.
• W1995194331 creator A5013051631 @default.
• W1995194331 creator A5016527233 @default.
• W1995194331 creator A5025017467 @default.
• W1995194331 creator A5027489586 @default.
• W1995194331 creator A5031611475 @default.
• W1995194331 creator A5034341014 @default.
• W1995194331 creator A5043707589 @default.
• W1995194331 creator A5047065171 @default.
• W1995194331 creator A5072737817 @default.
• W1995194331 creator A5072972205 @default.
• W1995194331 creator A5075804608 @default.
• W1995194331 creator A5087658253 @default.
• W1995194331 date "2008-11-05" @default.
• W1995194331 modified "2023-10-09" @default.
• W1995194331 title "A multidisciplinary study of patients with early-onset PD with and without parkin mutations" @default.
• W1995194331 cites W1877873625 @default.
• W1995194331 cites W1981515077 @default.
• W1995194331 cites W2000638346 @default.
• W1995194331 cites W2017865485 @default.
• W1995194331 cites W2036750918 @default.
• W1995194331 cites W2040140774 @default.
• W1995194331 cites W2072998862 @default.
• W1995194331 cites W2075039359 @default.
• W1995194331 cites W2083447600 @default.
• W1995194331 cites W2098525070 @default.
• W1995194331 cites W2101463726 @default.
• W1995194331 cites W2109183158 @default.
• W1995194331 cites W2113352333 @default.
• W1995194331 cites W2121642596 @default.
• W1995194331 cites W2124999533 @default.
• W1995194331 cites W2136000143 @default.
• W1995194331 cites W2139056264 @default.
• W1995194331 cites W2145036730 @default.
• W1995194331 cites W2151198603 @default.
• W1995194331 cites W2152756396 @default.
• W1995194331 cites W2166524215 @default.
• W1995194331 cites W2166606970 @default.
• W1995194331 cites W2317804643 @default.
• W1995194331 doi "https://doi.org/10.1212/01.wnl.0000327098.86861.d4" @default.
• W1995194331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2677494" @default.
• W1995194331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18987353" @default.
• W1995194331 hasPublicationYear "2008" @default.
• W1995194331 type Work @default.
• W1995194331 sameAs 1995194331 @default.
• W1995194331 citedByCount "81" @default.
• W1995194331 countsByYear W19951943312012 @default.
• W1995194331 countsByYear W19951943312013 @default.
• W1995194331 countsByYear W19951943312014 @default.
• W1995194331 countsByYear W19951943312015 @default.
• W1995194331 countsByYear W19951943312016 @default.
• W1995194331 countsByYear W19951943312017 @default.
• W1995194331 countsByYear W19951943312018 @default.
• W1995194331 countsByYear W19951943312019 @default.
• W1995194331 countsByYear W19951943312020 @default.
• W1995194331 countsByYear W19951943312021 @default.
• W1995194331 countsByYear W19951943312022 @default.
• W1995194331 countsByYear W19951943312023 @default.
• W1995194331 crossrefType "journal-article" @default.
• W1995194331 hasAuthorship W1995194331A5001020863 @default.
• W1995194331 hasAuthorship W1995194331A5013051631 @default.
• W1995194331 hasAuthorship W1995194331A5016527233 @default.
• W1995194331 hasAuthorship W1995194331A5025017467 @default.
• W1995194331 hasAuthorship W1995194331A5027489586 @default.
• W1995194331 hasAuthorship W1995194331A5031611475 @default.
• W1995194331 hasAuthorship W1995194331A5034341014 @default.
• W1995194331 hasAuthorship W1995194331A5043707589 @default.
• W1995194331 hasAuthorship W1995194331A5047065171 @default.
• W1995194331 hasAuthorship W1995194331A5072737817 @default.
• W1995194331 hasAuthorship W1995194331A5072972205 @default.
• W1995194331 hasAuthorship W1995194331A5075804608 @default.
• W1995194331 hasAuthorship W1995194331A5087658253 @default.
• W1995194331 hasBestOaLocation W19951943312 @default.
• W1995194331 hasConcept C118552586 @default.
• W1995194331 hasConcept C126322002 @default.
• W1995194331 hasConcept C137183658 @default.
• W1995194331 hasConcept C139719470 @default.
• W1995194331 hasConcept C14216870 @default.
• W1995194331 hasConcept C143998085 @default.
• W1995194331 hasConcept C15744967 @default.
• W1995194331 hasConcept C162324750 @default.
• W1995194331 hasConcept C169900460 @default.
• W1995194331 hasConcept C187212893 @default.
• W1995194331 hasConcept C2776525014 @default.
• W1995194331 hasConcept C2776773494 @default.
• W1995194331 hasConcept C2776867660 @default.
• W1995194331 hasConcept C2777668072 @default.
• W1995194331 hasConcept C2777767895 @default.
• W1995194331 hasConcept C2779134260 @default.
• W1995194331 hasConcept C2779483572 @default.
• W1995194331 hasConcept C2779734285 @default.
• W1995194331 hasConcept C2780304432 @default.
• W1995194331 hasConcept C2780938664 @default.
• W1995194331 hasConcept C513476851 @default.
• W1995194331 hasConcept C71924100 @default.
• W1995194331 hasConcept C90924648 @default.

• next