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• W1995199475 abstract "Insect neuropeptides are distributed in stereotypic sets of neurons that commonly constitute a small fraction of the total number of neurons. However, some neuropeptide genes are expressed in larger numbers of neurons of diverse types suggesting that they are involved in a greater diversity of functions. One of these widely expressed genes, snpf, encodes the precursor of short neuropeptide F (sNPF). To unravel possible functional diversity we have mapped the distribution of transcript of the snpf gene and its peptide products in the central nervous system (CNS) of Drosophila in relation to other neuronal markers. There are several hundreds of neurons in the larval CNS and several thousands in the adult Drosophila brain expressing snpf transcript and sNPF peptide. Most of these neurons are intrinsic interneurons of the mushroom bodies. Additionally, sNPF is expressed in numerous small interneurons of the CNS, olfactory receptor neurons (ORNs) of the antennae, and in a small set of possibly neurosecretory cells innervating the corpora cardiaca and aorta. A sNPF-Gal4 line confirms most of the expression pattern. None of the sNPF immunoreactive neurons co-express a marker for the transcription factor DIMMED, suggesting that the majority are not neurosecretory cells or large interneurons involved in episodic bulk transmission. Instead a portion of the sNPF producing neurons co-express markers for classical neurotransmitters such as acetylcholine, GABA and glutamate, suggesting that sNPF is a co-transmitter or local neuromodulator in ORNs and many interneurons. Interestingly, sNPF is coexpressed both with presumed excitatory and inhibitory neurotransmitters. A few sNPF expressing neurons in the brain colocalize the peptide corazonin and a pair of dorsal neurons in the first abdominal neuromere coexpresses sNPF and insulin-like peptide 7 (ILP7). It is likely that sNPF has multiple functions as neurohormone as well as local neuromodulator/co-transmitter in various CNS circuits, including olfactory circuits both at the level of the first synapse and at the mushroom body output level. Some of the sNPF immunoreactive axons terminate in close proximity to neurosecretory cells producing ILPs and adipokinetic hormone, indicating that sNPF also might regulate hormone production or release." @default.
• W1995199475 created "2016-06-24" @default.
• W1995199475 creator A5000832298 @default.
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• W1995199475 creator A5073366463 @default.
• W1995199475 creator A5086090685 @default.
• W1995199475 date "2008-09-19" @default.
• W1995199475 modified "2023-10-11" @default.
• W1995199475 title "A large population of diverse neurons in the Drosophilacentral nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions" @default.
• W1995199475 cites W1536628940 @default.
• W1995199475 cites W1555593125 @default.
• W1995199475 cites W1569022587 @default.
• W1995199475 cites W1578469909 @default.
• W1995199475 cites W162318695 @default.
• W1995199475 cites W1679735257 @default.
• W1995199475 cites W1919157514 @default.
• W1995199475 cites W1964294572 @default.
• W1995199475 cites W1964430873 @default.
• W1995199475 cites W1965744669 @default.
• W1995199475 cites W1966382974 @default.
• W1995199475 cites W1966799860 @default.
• W1995199475 cites W1967003765 @default.
• W1995199475 cites W1968010393 @default.
• W1995199475 cites W1970727542 @default.
• W1995199475 cites W1974521803 @default.
• W1995199475 cites W1974745077 @default.
• W1995199475 cites W1974833033 @default.
• W1995199475 cites W1975894526 @default.
• W1995199475 cites W1977264444 @default.
• W1995199475 cites W1977482774 @default.
• W1995199475 cites W1981583374 @default.
• W1995199475 cites W1985895078 @default.
• W1995199475 cites W1988331575 @default.
• W1995199475 cites W1989965174 @default.
• W1995199475 cites W1991983145 @default.
• W1995199475 cites W1992759659 @default.
• W1995199475 cites W1995005137 @default.
• W1995199475 cites W1995503870 @default.
• W1995199475 cites W1997111440 @default.
• W1995199475 cites W1998168987 @default.
• W1995199475 cites W1999217200 @default.
• W1995199475 cites W2006805865 @default.
• W1995199475 cites W2008382463 @default.
• W1995199475 cites W2014845998 @default.
• W1995199475 cites W2015832139 @default.
• W1995199475 cites W2019754186 @default.
• W1995199475 cites W2022952303 @default.
• W1995199475 cites W2030026428 @default.
• W1995199475 cites W2031811351 @default.
• W1995199475 cites W2036793785 @default.
• W1995199475 cites W2038718458 @default.
• W1995199475 cites W2039528431 @default.
• W1995199475 cites W2042682804 @default.
• W1995199475 cites W2045210487 @default.
• W1995199475 cites W2046656052 @default.
• W1995199475 cites W2048054368 @default.
• W1995199475 cites W2048063102 @default.
• W1995199475 cites W2051645401 @default.
• W1995199475 cites W2052438257 @default.
• W1995199475 cites W2062394518 @default.
• W1995199475 cites W2062656302 @default.
• W1995199475 cites W2063747312 @default.
• W1995199475 cites W2064735564 @default.
• W1995199475 cites W2070405413 @default.
• W1995199475 cites W2070925479 @default.
• W1995199475 cites W2071202857 @default.
• W1995199475 cites W2073257428 @default.
• W1995199475 cites W2076766773 @default.
• W1995199475 cites W2078866571 @default.
• W1995199475 cites W2081822203 @default.
• W1995199475 cites W2083850113 @default.
• W1995199475 cites W2087693296 @default.
• W1995199475 cites W2088305507 @default.
• W1995199475 cites W2088599563 @default.
• W1995199475 cites W2091112084 @default.
• W1995199475 cites W2101782576 @default.
• W1995199475 cites W2103542900 @default.
• W1995199475 cites W2106297617 @default.
• W1995199475 cites W2118398316 @default.
• W1995199475 cites W2121339588 @default.
• W1995199475 cites W2123673861 @default.
• W1995199475 cites W2125166457 @default.
• W1995199475 cites W2128762625 @default.
• W1995199475 cites W2131424500 @default.
• W1995199475 cites W2142135550 @default.
• W1995199475 cites W2154414197 @default.
• W1995199475 cites W2155458372 @default.
• W1995199475 cites W2167061161 @default.
• W1995199475 cites W2170719164 @default.
• W1995199475 cites W2334361384 @default.
• W1995199475 cites W2400535777 @default.
• W1995199475 cites W2912942392 @default.
• W1995199475 cites W4241561654 @default.
• W1995199475 doi "https://doi.org/10.1186/1471-2202-9-90" @default.
• W1995199475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2569041" @default.
• W1995199475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18803813" @default.
• W1995199475 hasPublicationYear "2008" @default.
• W1995199475 type Work @default.
• W1995199475 sameAs 1995199475 @default.

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