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- W1995202316 abstract "One way mixed lymphocyte reactions (MLR) were used to determine how in vivo tumor growth affects in vitro macrophage-T-cell interactions. When normal T-cells were used, reactivity to allogeneic cells required macrophages. In contrast, the nonadherent spleen cell population from week old tumor-bearing mice responded without additional macrophages. At all concentrations, addition of exogenous macrophages enhanced the MLR. Macrophages from normal as well as tumor-bearing mice (TBM) when treated with anti-theta serum and complement exhibited no inhibitory activity towards normal nylon wool nonadherent (NA) T-cells, at concentrations ranging up to 24%. Macrophage enhancement was not contact dependent, though the degree of enhanced activity was dependent upon the host stage of tumor development. During initial phases of tumor growth, T-cell reactivity was maximally enhanced by the presence of normal or TBM macrophages. In the late stages of tumor development, T-cells, when exposed to macrophages from normal or TBM, exhibited a subnormal level of reactivity. Though no in vitro macrophage inhibition of T-cell MLR activity could be detected, experiments are currently being conducted to determine the extent of macrophage involvement in the degeneration of the T-cell immune response during late stages of tumor growth." @default.
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- W1995202316 date "1978-01-01" @default.
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- W1995202316 title "Macrophage regulation of the T-cell allogeneic response during tumor growth" @default.
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- W1995202316 doi "https://doi.org/10.1016/0008-8749(78)90121-1" @default.
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