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- W1995204029 abstract "1. Ouabain induced concentration-dependent contractions in segments of human placental arteries and veins, which were practically abolished in a Ca2+-free medium and not modified by the calcium antagonist nifedipine or the calcium agonist Bay K 8644. 2. Ouabain (10−4 M) elicited a time-dependent enhancement of the 45Ca2+ uptake, which remained equal in presence of nifedipine or Bay K 8644. 3. The Na+/Ca2+ exchange blocker amiloride reduced both the contractions and the 45Ca2+ uptake induced by ouabain, whereas the Na ionophore monensin produced a parallel shift to the left of the concentration-response curve to ouabain. 4. These results suggest that ouabain-induced contractions in these vessels are dependent on the extracellular Ca2+, which mainly enters into the cell through the Na+/Ca2+ exchange system." @default.
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- W1995204029 date "1992-05-01" @default.
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- W1995204029 title "Na+/Ca2+ exchange mediation in the ouabain-induced contraction in human placental vessels" @default.
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- W1995204029 doi "https://doi.org/10.1016/0306-3623(92)90109-w" @default.
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