Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995205178> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1995205178 endingPage "329" @default.
- W1995205178 startingPage "320" @default.
- W1995205178 abstract "Toxoplasma gondii is a zoonotic parasite and its infection in human can induce toxoplasmic encephalitis in immune disorders. In this study, astroglia were infected with the TS-4 strain of T. gondii tachyzoite in vitro to investigate the changes of matrix metalloproteinase (MMP)-2, MMP-9 and their substrate fibronectin. MMP-2 and MMP-9 were significantly increased at 1 h, 6 h and 12 h post-infection (PI) in the cell homogenates, and increased at 6 h, 12 h, 24 h and 48 h PI in the cell-cultured supernatants. Fibronectin degradation also occurred at the same time points. In addition, immunocytochemistry showed that MMP-2 and MMP-9 localized in the cytoplasm, and confocal scanning laser microscopy revealed co-labeled patterns of MMP-2 and MMP-9 with fibronectin. MMP-2 and MMP-9 interacted with fibronectin, respectively. These results suggest that MMP-2 and MMP-9 induction from astroglia may contribute to extracellular matrix (ECM) degradation occurring in toxoplasmosis. Thus, we hypothesize that MMP-2 and MMP-9 cleave fibronectin and may contribute to the astroglia reaction and leukocyte migration to the sites of T. gondii replication during toxoplasmic encephalitis." @default.
- W1995205178 created "2016-06-24" @default.
- W1995205178 creator A5013440267 @default.
- W1995205178 creator A5079640803 @default.
- W1995205178 date "2013-03-01" @default.
- W1995205178 modified "2023-09-24" @default.
- W1995205178 title "Matrix metalloproteinase-2 and -9 lead to fibronectin degradation in astroglia infected with Toxoplasma gondii" @default.
- W1995205178 cites W1848937020 @default.
- W1995205178 cites W1965147697 @default.
- W1995205178 cites W1970458434 @default.
- W1995205178 cites W1970898900 @default.
- W1995205178 cites W1998557118 @default.
- W1995205178 cites W2024051243 @default.
- W1995205178 cites W2030126554 @default.
- W1995205178 cites W2037655228 @default.
- W1995205178 cites W2040860165 @default.
- W1995205178 cites W2053793074 @default.
- W1995205178 cites W2064338748 @default.
- W1995205178 cites W2065654101 @default.
- W1995205178 cites W2069076166 @default.
- W1995205178 cites W2077123765 @default.
- W1995205178 cites W2081013536 @default.
- W1995205178 cites W2081961074 @default.
- W1995205178 cites W2085683193 @default.
- W1995205178 cites W2092302260 @default.
- W1995205178 cites W2114413554 @default.
- W1995205178 cites W2117066155 @default.
- W1995205178 cites W2131481885 @default.
- W1995205178 cites W2138406651 @default.
- W1995205178 cites W2164656801 @default.
- W1995205178 cites W2313048608 @default.
- W1995205178 cites W3025190738 @default.
- W1995205178 doi "https://doi.org/10.1016/j.actatropica.2012.11.002" @default.
- W1995205178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23201304" @default.
- W1995205178 hasPublicationYear "2013" @default.
- W1995205178 type Work @default.
- W1995205178 sameAs 1995205178 @default.
- W1995205178 citedByCount "17" @default.
- W1995205178 countsByYear W19952051782013 @default.
- W1995205178 countsByYear W19952051782014 @default.
- W1995205178 countsByYear W19952051782015 @default.
- W1995205178 countsByYear W19952051782018 @default.
- W1995205178 countsByYear W19952051782020 @default.
- W1995205178 countsByYear W19952051782021 @default.
- W1995205178 countsByYear W19952051782022 @default.
- W1995205178 countsByYear W19952051782023 @default.
- W1995205178 crossrefType "journal-article" @default.
- W1995205178 hasAuthorship W1995205178A5013440267 @default.
- W1995205178 hasAuthorship W1995205178A5079640803 @default.
- W1995205178 hasConcept C109523444 @default.
- W1995205178 hasConcept C153911025 @default.
- W1995205178 hasConcept C159047783 @default.
- W1995205178 hasConcept C159654299 @default.
- W1995205178 hasConcept C189165786 @default.
- W1995205178 hasConcept C203014093 @default.
- W1995205178 hasConcept C2778062946 @default.
- W1995205178 hasConcept C2778128430 @default.
- W1995205178 hasConcept C55493867 @default.
- W1995205178 hasConcept C86492073 @default.
- W1995205178 hasConcept C86803240 @default.
- W1995205178 hasConcept C89423630 @default.
- W1995205178 hasConcept C95444343 @default.
- W1995205178 hasConceptScore W1995205178C109523444 @default.
- W1995205178 hasConceptScore W1995205178C153911025 @default.
- W1995205178 hasConceptScore W1995205178C159047783 @default.
- W1995205178 hasConceptScore W1995205178C159654299 @default.
- W1995205178 hasConceptScore W1995205178C189165786 @default.
- W1995205178 hasConceptScore W1995205178C203014093 @default.
- W1995205178 hasConceptScore W1995205178C2778062946 @default.
- W1995205178 hasConceptScore W1995205178C2778128430 @default.
- W1995205178 hasConceptScore W1995205178C55493867 @default.
- W1995205178 hasConceptScore W1995205178C86492073 @default.
- W1995205178 hasConceptScore W1995205178C86803240 @default.
- W1995205178 hasConceptScore W1995205178C89423630 @default.
- W1995205178 hasConceptScore W1995205178C95444343 @default.
- W1995205178 hasFunder F4320321040 @default.
- W1995205178 hasFunder F4320321408 @default.
- W1995205178 hasFunder F4320325266 @default.
- W1995205178 hasIssue "3" @default.
- W1995205178 hasLocation W19952051781 @default.
- W1995205178 hasLocation W19952051782 @default.
- W1995205178 hasOpenAccess W1995205178 @default.
- W1995205178 hasPrimaryLocation W19952051781 @default.
- W1995205178 hasRelatedWork W100934462 @default.
- W1995205178 hasRelatedWork W1967728126 @default.
- W1995205178 hasRelatedWork W1987669338 @default.
- W1995205178 hasRelatedWork W2084855627 @default.
- W1995205178 hasRelatedWork W2133685356 @default.
- W1995205178 hasRelatedWork W2399026859 @default.
- W1995205178 hasRelatedWork W2416997590 @default.
- W1995205178 hasRelatedWork W3202124842 @default.
- W1995205178 hasRelatedWork W4291743458 @default.
- W1995205178 hasRelatedWork W2179426006 @default.
- W1995205178 hasVolume "125" @default.
- W1995205178 isParatext "false" @default.
- W1995205178 isRetracted "false" @default.
- W1995205178 magId "1995205178" @default.
- W1995205178 workType "article" @default.