Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995205815> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1995205815 endingPage "225" @default.
- W1995205815 startingPage "219" @default.
- W1995205815 abstract "Subcutaneous granulomas were induced in rats by viscose cellulose-sponge and allowed to develop for 7 or 21 days. Before sacrificing the rats were treated for 5 days with antirheumatic drugs: sodium acetylsalicylate 300 mg/kg per day, prednisolone 1 and 10 mg/kg per day, indomethacin 0.1 and 10 mg/kg per day or phenylbutazone 100 mg/kg/day. The contents of DNA and especially of RNA in the granulomas were decreased, and the incorporation of 3H-cytidine into DNA in vitro was suppressed. The amounts of total nitrogen and of hydroxyproline (and consequently of collagen) were decreased. The incorporation of 3H-proline into proteins of granuloma slices was also decreased, except after treatment with the moderate dose of indomethacin, which apparently increased the incorporation of proline into collagenous proteins. This paradoxical effect of indomethacin is discussed. The content of total hexosamine was also decreased but that of uronic acids was increased. It is suggested that by multiple mechanisms the antirheumatic drugs retard the development of granulation tissue, but not the synthesis of acid mucopolysaccharides. At the proliferative phase the granulomas are more sensitive to the drugs than at the mature phase, and the incorporation rates are more affected than the total amounts of nitrogenous components." @default.
- W1995205815 created "2016-06-24" @default.
- W1995205815 creator A5009146540 @default.
- W1995205815 creator A5028769951 @default.
- W1995205815 date "1975-01-01" @default.
- W1995205815 modified "2023-09-25" @default.
- W1995205815 title "Effect of the administration of antirheumatic drugs on experimental granuloma in rat" @default.
- W1995205815 cites W1484536008 @default.
- W1995205815 cites W1774817685 @default.
- W1995205815 cites W1906197854 @default.
- W1995205815 cites W1980791075 @default.
- W1995205815 cites W1990579848 @default.
- W1995205815 cites W1993524986 @default.
- W1995205815 cites W1999652145 @default.
- W1995205815 cites W2020471728 @default.
- W1995205815 cites W2023755198 @default.
- W1995205815 cites W2027950392 @default.
- W1995205815 cites W2028925121 @default.
- W1995205815 cites W2034462747 @default.
- W1995205815 cites W2094841735 @default.
- W1995205815 cites W2408705523 @default.
- W1995205815 cites W2414613608 @default.
- W1995205815 cites W4317640641 @default.
- W1995205815 doi "https://doi.org/10.1016/0006-2952(75)90280-4" @default.
- W1995205815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1111535" @default.
- W1995205815 hasPublicationYear "1975" @default.
- W1995205815 type Work @default.
- W1995205815 sameAs 1995205815 @default.
- W1995205815 citedByCount "34" @default.
- W1995205815 crossrefType "journal-article" @default.
- W1995205815 hasAuthorship W1995205815A5009146540 @default.
- W1995205815 hasAuthorship W1995205815A5028769951 @default.
- W1995205815 hasConcept C126322002 @default.
- W1995205815 hasConcept C134018914 @default.
- W1995205815 hasConcept C185592680 @default.
- W1995205815 hasConcept C203014093 @default.
- W1995205815 hasConcept C2775844104 @default.
- W1995205815 hasConcept C2776055305 @default.
- W1995205815 hasConcept C2779797417 @default.
- W1995205815 hasConcept C2780140890 @default.
- W1995205815 hasConcept C2780269544 @default.
- W1995205815 hasConcept C55493867 @default.
- W1995205815 hasConcept C71924100 @default.
- W1995205815 hasConcept C86803240 @default.
- W1995205815 hasConcept C98274493 @default.
- W1995205815 hasConceptScore W1995205815C126322002 @default.
- W1995205815 hasConceptScore W1995205815C134018914 @default.
- W1995205815 hasConceptScore W1995205815C185592680 @default.
- W1995205815 hasConceptScore W1995205815C203014093 @default.
- W1995205815 hasConceptScore W1995205815C2775844104 @default.
- W1995205815 hasConceptScore W1995205815C2776055305 @default.
- W1995205815 hasConceptScore W1995205815C2779797417 @default.
- W1995205815 hasConceptScore W1995205815C2780140890 @default.
- W1995205815 hasConceptScore W1995205815C2780269544 @default.
- W1995205815 hasConceptScore W1995205815C55493867 @default.
- W1995205815 hasConceptScore W1995205815C71924100 @default.
- W1995205815 hasConceptScore W1995205815C86803240 @default.
- W1995205815 hasConceptScore W1995205815C98274493 @default.
- W1995205815 hasIssue "2" @default.
- W1995205815 hasLocation W19952058151 @default.
- W1995205815 hasLocation W19952058152 @default.
- W1995205815 hasOpenAccess W1995205815 @default.
- W1995205815 hasPrimaryLocation W19952058151 @default.
- W1995205815 hasRelatedWork W1966464627 @default.
- W1995205815 hasRelatedWork W1970861121 @default.
- W1995205815 hasRelatedWork W1979139803 @default.
- W1995205815 hasRelatedWork W1990579848 @default.
- W1995205815 hasRelatedWork W1995205815 @default.
- W1995205815 hasRelatedWork W2049047086 @default.
- W1995205815 hasRelatedWork W2082303901 @default.
- W1995205815 hasRelatedWork W2089937983 @default.
- W1995205815 hasRelatedWork W2408354580 @default.
- W1995205815 hasRelatedWork W2748952813 @default.
- W1995205815 hasVolume "24" @default.
- W1995205815 isParatext "false" @default.
- W1995205815 isRetracted "false" @default.
- W1995205815 magId "1995205815" @default.
- W1995205815 workType "article" @default.