FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995226018> ?p ?o ?g. }

• W1995226018 endingPage "768" @default.
• W1995226018 startingPage "759" @default.
• W1995226018 abstract "Development of resistance to 1-β-arabinofuranosylcytosine (AraC) is a major obstacle in the treatment of patients with acute myeloid leukaemia (AML). Deficiency of functional deoxycytidine kinase (dCK) plays an important role in AraC resistance in vitro. We screened 5378 bp sequences of the dCK gene, including all exons and the 5′ flanking region, and identified two single nucleotide polymorphisms (SNPs) in the regulatory region (rSNPs) with high allele frequencies. These two rSNPs (−201C>T and −360C>G) formed two major haplotypes. Genotyping with sequencing and MassARRAY system among 122 AML patients showed that those with −360CG/−201CT and −360GG/−201TT compound genotypes (n = 41) displayed a favourable response to chemotherapy whereas those with −360CC/−201CC (n = 81) tended to have a poor response (P = 0.025). Moreover, real-time quantitative reverse transcriptase-polymerase chain reaction showed that patients with −360CG/−201CT and −360GG/−201TT genotypes expressed higher level of dCK mRNA compared to those with the −360CC/−201CC genotype (P = 0.0034). Luciferase-reporter assay showed that dCK 5′ regulatory region bearing −360G/−201T genotype alone had an eight-fold greater transcriptional activation activity compared to that with −360C/−201C genotype, whereas co-transfection of both −360G/−201T and −360C/−201C constructs mimicked the heterozygous genotype, which exhibited a four-fold greater activity compared to that with −360C/−201C. These results indicate that rSNP haplotypes of dCK gene may serve as a genetic marker for predicting drug responsiveness, which will be beneficial in establishing more effective AML chemotherapeutic regimens." @default.
• W1995226018 created "2016-06-24" @default.
• W1995226018 creator A5010345121 @default.
• W1995226018 creator A5025071259 @default.
• W1995226018 creator A5025570473 @default.
• W1995226018 creator A5026487938 @default.
• W1995226018 creator A5029640120 @default.
• W1995226018 creator A5058401524 @default.
• W1995226018 creator A5058588514 @default.
• W1995226018 creator A5061648551 @default.
• W1995226018 creator A5077066897 @default.
• W1995226018 creator A5082424766 @default.
• W1995226018 creator A5084191419 @default.
• W1995226018 creator A5086332136 @default.
• W1995226018 creator A5090253956 @default.
• W1995226018 date "2004-11-01" @default.
• W1995226018 modified "2023-09-22" @default.
• W1995226018 title "Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients" @default.
• W1995226018 cites W1501974728 @default.
• W1995226018 cites W1547936640 @default.
• W1995226018 cites W1595767711 @default.
• W1995226018 cites W1969770714 @default.
• W1995226018 cites W1971307410 @default.
• W1995226018 cites W1973364327 @default.
• W1995226018 cites W1981986388 @default.
• W1995226018 cites W1995927666 @default.
• W1995226018 cites W2006322387 @default.
• W1995226018 cites W2012151258 @default.
• W1995226018 cites W2024913341 @default.
• W1995226018 cites W2042814209 @default.
• W1995226018 cites W2045467759 @default.
• W1995226018 cites W2051712676 @default.
• W1995226018 cites W2056226887 @default.
• W1995226018 cites W2061909512 @default.
• W1995226018 cites W2064879068 @default.
• W1995226018 cites W2082275089 @default.
• W1995226018 cites W2093577257 @default.
• W1995226018 cites W2094184203 @default.
• W1995226018 cites W2095399864 @default.
• W1995226018 cites W2095422595 @default.
• W1995226018 cites W2103975836 @default.
• W1995226018 cites W2105682384 @default.
• W1995226018 cites W2114212405 @default.
• W1995226018 cites W2151347057 @default.
• W1995226018 cites W2158438223 @default.
• W1995226018 cites W2164154631 @default.
• W1995226018 cites W2171300427 @default.
• W1995226018 cites W2318674152 @default.
• W1995226018 cites W2345653340 @default.
• W1995226018 cites W41336079 @default.
• W1995226018 cites W47789525 @default.
• W1995226018 cites W49953563 @default.
• W1995226018 doi "https://doi.org/10.1097/00008571-200411000-00007" @default.
• W1995226018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15564883" @default.
• W1995226018 hasPublicationYear "2004" @default.
• W1995226018 type Work @default.
• W1995226018 sameAs 1995226018 @default.
• W1995226018 citedByCount "71" @default.
• W1995226018 countsByYear W19952260182012 @default.
• W1995226018 countsByYear W19952260182013 @default.
• W1995226018 countsByYear W19952260182014 @default.
• W1995226018 countsByYear W19952260182015 @default.
• W1995226018 countsByYear W19952260182016 @default.
• W1995226018 countsByYear W19952260182017 @default.
• W1995226018 countsByYear W19952260182018 @default.
• W1995226018 countsByYear W19952260182019 @default.
• W1995226018 countsByYear W19952260182021 @default.
• W1995226018 countsByYear W19952260182022 @default.
• W1995226018 crossrefType "journal-article" @default.
• W1995226018 hasAuthorship W1995226018A5010345121 @default.
• W1995226018 hasAuthorship W1995226018A5025071259 @default.
• W1995226018 hasAuthorship W1995226018A5025570473 @default.
• W1995226018 hasAuthorship W1995226018A5026487938 @default.
• W1995226018 hasAuthorship W1995226018A5029640120 @default.
• W1995226018 hasAuthorship W1995226018A5058401524 @default.
• W1995226018 hasAuthorship W1995226018A5058588514 @default.
• W1995226018 hasAuthorship W1995226018A5061648551 @default.
• W1995226018 hasAuthorship W1995226018A5077066897 @default.
• W1995226018 hasAuthorship W1995226018A5082424766 @default.
• W1995226018 hasAuthorship W1995226018A5084191419 @default.
• W1995226018 hasAuthorship W1995226018A5086332136 @default.
• W1995226018 hasAuthorship W1995226018A5090253956 @default.
• W1995226018 hasConcept C104317684 @default.
• W1995226018 hasConcept C135763542 @default.
• W1995226018 hasConcept C153209595 @default.
• W1995226018 hasConcept C153911025 @default.
• W1995226018 hasConcept C180754005 @default.
• W1995226018 hasConcept C197754878 @default.
• W1995226018 hasConcept C2776694085 @default.
• W1995226018 hasConcept C2777844706 @default.
• W1995226018 hasConcept C2778041864 @default.
• W1995226018 hasConcept C2779268695 @default.
• W1995226018 hasConcept C2780258809 @default.
• W1995226018 hasConcept C31467283 @default.
• W1995226018 hasConcept C502942594 @default.
• W1995226018 hasConcept C54355233 @default.
• W1995226018 hasConcept C86803240 @default.
• W1995226018 hasConceptScore W1995226018C104317684 @default.

• next