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• W1995233669 abstract "Background: Conventional therapy for osteosarcoma has reached a plateau of 60 – 70%, a 5-year survival rate that has changed little in two decades, highlighting the need for new approaches. Objective: To review the alternative means of delivering effective therapy for osteosarcoma that reach beyond the central venous catheter. Methods: Drawing on the author's own experiences providing care to high-risk osteosarcoma patients and reviewing the last two decades of literature describing sarcoma therapy, available information is summarized about potential osteosarcoma treatments that deliver therapy by a less conventional route. Results/conclusions: Intra-arterial chemotherapy has a limited impact on survival, but may help to achieve a better limb salvage. Intrapleural chemotherapy is important for managing malignant effusions. The development of inhalation therapies, treatments that target new bone formation such as bisphosphonates, chemically targeted radiation and antibody-based therapies all have potential to improve osteosarcoma therapy." @default.
• W1995233669 created "2016-06-24" @default.
• W1995233669 creator A5077235997 @default.
• W1995233669 date "2009-09-18" @default.
• W1995233669 modified "2023-09-26" @default.
• W1995233669 title "Strategies for the targeted delivery of therapeutics for osteosarcoma" @default.
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• W1995233669 doi "https://doi.org/10.1517/17425240903280422" @default.
• W1995233669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4163784" @default.
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